HTR1E protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HTR1E

5-hydroxytryptamine receptor 1E; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). (365 aa)

Predicted Functional Partners:

GNB1

0.955

GNAI1

0.944

GNG2

0.925

GNB4

0.846

GNAI3

0.829

GNB2

0.829

GNAI2

0.807

GNG4

0.790

GNG7

0.783

GNB3

0.776

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNAI1	GNAI2	ENSPTRP00000071974	ENSPTRP00000025802	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	0.973
GNAI1	GNAI3	ENSPTRP00000071974	ENSPTRP00000001821	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.985
GNAI1	GNB1	ENSPTRP00000071974	ENSPTRP00000067330	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.998
GNAI1	GNB2	ENSPTRP00000071974	ENSPTRP00000085287	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.943
GNAI1	GNB3	ENSPTRP00000071974	ENSPTRP00000045189	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	G protein subunit beta 3.	0.891
GNAI1	GNB4	ENSPTRP00000071974	ENSPTRP00000026924	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), beta polypeptide 4.	0.957
GNAI1	GNG2	ENSPTRP00000071974	ENSPTRP00000065345	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.995
GNAI1	GNG4	ENSPTRP00000071974	ENSPTRP00000003602	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.949
GNAI1	GNG7	ENSPTRP00000071974	ENSPTRP00000069136	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.958
GNAI1	HTR1E	ENSPTRP00000071974	ENSPTRP00000056988	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	5-hydroxytryptamine receptor 1E; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity).	0.944
GNAI2	GNAI1	ENSPTRP00000025802	ENSPTRP00000071974	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	0.973
GNAI2	GNAI3	ENSPTRP00000025802	ENSPTRP00000001821	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.992
GNAI2	GNB1	ENSPTRP00000025802	ENSPTRP00000067330	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.997
GNAI2	GNB2	ENSPTRP00000025802	ENSPTRP00000085287	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.934
GNAI2	GNB3	ENSPTRP00000025802	ENSPTRP00000045189	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	G protein subunit beta 3.	0.901
GNAI2	GNB4	ENSPTRP00000025802	ENSPTRP00000026924	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide binding protein (G protein), beta polypeptide 4.	0.950
GNAI2	GNG2	ENSPTRP00000025802	ENSPTRP00000065345	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.956
GNAI2	GNG4	ENSPTRP00000025802	ENSPTRP00000003602	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.926
GNAI2	GNG7	ENSPTRP00000025802	ENSPTRP00000069136	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.937
GNAI2	HTR1E	ENSPTRP00000025802	ENSPTRP00000056988	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	5-hydroxytryptamine receptor 1E; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity).	0.807

page 1 of 6

Server load: low (22%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About