CERS6 protein (Pan troglodytes) - STRING interaction network

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Score

CERS6

Ceramide synthase 6. (392 aa)

Predicted Functional Partners:

DEGS1

0.960

KDSR

0.954

ASAH1

0.954

DEGS2

0.953

SMPD1

0.949

UGCG

0.949

SGMS1

0.944

SPHK2

0.944

SMPD2

0.944

SPHK1

0.944

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASAH1	CERS6	ENSPTRP00000063559	ENSPTRP00000067582	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Ceramide synthase 6.	0.954
ASAH1	DEGS1	ENSPTRP00000063559	ENSPTRP00000003391	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Degenerative spermatocyte homolog 1, lipid desaturase.	0.944
ASAH1	DEGS2	ENSPTRP00000063559	ENSPTRP00000011449	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Delta 4-desaturase, sphingolipid 2.	0.928
ASAH1	KDSR	ENSPTRP00000063559	ENSPTRP00000017122	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.937
ASAH1	SGMS1	ENSPTRP00000063559	ENSPTRP00000004317	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingomyelin synthase 1.	0.943
ASAH1	SMPD1	ENSPTRP00000063559	ENSPTRP00000005756	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.968
ASAH1	SMPD2	ENSPTRP00000063559	ENSPTRP00000031570	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingomyelin phosphodiesterase 2, neutral membrane (Neutral sphingomyelinase).	0.948
ASAH1	SPHK1	ENSPTRP00000063559	ENSPTRP00000052717	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingosine kinase 1.	0.964
ASAH1	SPHK2	ENSPTRP00000063559	ENSPTRP00000019290	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingosine kinase 2.	0.963
ASAH1	UGCG	ENSPTRP00000063559	ENSPTRP00000065363	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	UDP-glucose ceramide glucosyltransferase.	0.953
CERS6	ASAH1	ENSPTRP00000067582	ENSPTRP00000063559	Ceramide synthase 6.	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	0.954
CERS6	DEGS1	ENSPTRP00000067582	ENSPTRP00000003391	Ceramide synthase 6.	Degenerative spermatocyte homolog 1, lipid desaturase.	0.960
CERS6	DEGS2	ENSPTRP00000067582	ENSPTRP00000011449	Ceramide synthase 6.	Delta 4-desaturase, sphingolipid 2.	0.953
CERS6	KDSR	ENSPTRP00000067582	ENSPTRP00000017122	Ceramide synthase 6.	3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.954
CERS6	SGMS1	ENSPTRP00000067582	ENSPTRP00000004317	Ceramide synthase 6.	Sphingomyelin synthase 1.	0.944
CERS6	SMPD1	ENSPTRP00000067582	ENSPTRP00000005756	Ceramide synthase 6.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.949
CERS6	SMPD2	ENSPTRP00000067582	ENSPTRP00000031570	Ceramide synthase 6.	Sphingomyelin phosphodiesterase 2, neutral membrane (Neutral sphingomyelinase).	0.944
CERS6	SPHK1	ENSPTRP00000067582	ENSPTRP00000052717	Ceramide synthase 6.	Sphingosine kinase 1.	0.944
CERS6	SPHK2	ENSPTRP00000067582	ENSPTRP00000019290	Ceramide synthase 6.	Sphingosine kinase 2.	0.944
CERS6	UGCG	ENSPTRP00000067582	ENSPTRP00000065363	Ceramide synthase 6.	UDP-glucose ceramide glucosyltransferase.	0.949