SIX6 protein (Pan troglodytes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

SIX6

SIX homeobox 6. (246 aa)

Predicted Functional Partners:

FAM92B

0.848

SPINK6

0.826

SPINK14

0.826

DSTYK

0.699

OTX2

0.695

DACH1

0.688

RHOH

0.669

TMEM132B

0.606

TMEM132D

0.606

EYA2

0.586

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DACH1	EYA2	ENSPTRP00000010068	ENSPTRP00000092549	DACH1 isoform 4.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.636
DACH1	SIX6	ENSPTRP00000010068	ENSPTRP00000010877	DACH1 isoform 4.	SIX homeobox 6.	0.688
DSTYK	FAM92B	ENSPTRP00000003173	ENSPTRP00000014379	Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.	Family with sequence similarity 92 member B.	0.844
DSTYK	RHOH	ENSPTRP00000003173	ENSPTRP00000091785	Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.	RHOH isoform 10.	0.704
DSTYK	SIX6	ENSPTRP00000003173	ENSPTRP00000010877	Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.	SIX homeobox 6.	0.699
DSTYK	SPINK14	ENSPTRP00000003173	ENSPTRP00000080870	Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.	Serine peptidase inhibitor, Kazal type 14 (putative).	0.916
DSTYK	SPINK6	ENSPTRP00000003173	ENSPTRP00000029712	Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.	Serine peptidase inhibitor, Kazal type 6.	0.916
EYA2	DACH1	ENSPTRP00000092549	ENSPTRP00000010068	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	DACH1 isoform 4.	0.636
EYA2	SIX6	ENSPTRP00000092549	ENSPTRP00000010877	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 6.	0.586
FAM92B	DSTYK	ENSPTRP00000014379	ENSPTRP00000003173	Family with sequence similarity 92 member B.	Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.	0.844
FAM92B	RHOH	ENSPTRP00000014379	ENSPTRP00000091785	Family with sequence similarity 92 member B.	RHOH isoform 10.	0.790
FAM92B	SIX6	ENSPTRP00000014379	ENSPTRP00000010877	Family with sequence similarity 92 member B.	SIX homeobox 6.	0.848
FAM92B	SPINK14	ENSPTRP00000014379	ENSPTRP00000080870	Family with sequence similarity 92 member B.	Serine peptidase inhibitor, Kazal type 14 (putative).	0.888
FAM92B	SPINK6	ENSPTRP00000014379	ENSPTRP00000029712	Family with sequence similarity 92 member B.	Serine peptidase inhibitor, Kazal type 6.	0.889
OTX2	SIX6	ENSPTRP00000010823	ENSPTRP00000010877	Orthodenticle homeobox 2.	SIX homeobox 6.	0.695
RHOH	DSTYK	ENSPTRP00000091785	ENSPTRP00000003173	RHOH isoform 10.	Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.	0.704
RHOH	FAM92B	ENSPTRP00000091785	ENSPTRP00000014379	RHOH isoform 10.	Family with sequence similarity 92 member B.	0.790
RHOH	SIX6	ENSPTRP00000091785	ENSPTRP00000010877	RHOH isoform 10.	SIX homeobox 6.	0.669
RHOH	SPINK14	ENSPTRP00000091785	ENSPTRP00000080870	RHOH isoform 10.	Serine peptidase inhibitor, Kazal type 14 (putative).	0.761
RHOH	SPINK6	ENSPTRP00000091785	ENSPTRP00000029712	RHOH isoform 10.	Serine peptidase inhibitor, Kazal type 6.	0.761