THOP1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	KNG1	ENSPTRP00000038991	ENSPTRP00000065338	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	KNG1 isoform 2.	0.975
ACE	REN	ENSPTRP00000038991	ENSPTRP00000051292	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.	0.991
ACE	THOP1	ENSPTRP00000038991	ENSPTRP00000057817	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Thimet oligopeptidase 1.	0.935
CIB1	CRADD	ENSPTRP00000012735	ENSPTRP00000087931	Calcium and integrin binding 1.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.774
CIB1	GPR37	ENSPTRP00000012735	ENSPTRP00000033642	Calcium and integrin binding 1.	G protein-coupled receptor 37.	0.834
CIB1	GRIN3A	ENSPTRP00000012735	ENSPTRP00000039833	Calcium and integrin binding 1.	GRIN3A isoform 1.	0.820
CIB1	LUM	ENSPTRP00000012735	ENSPTRP00000008987	Calcium and integrin binding 1.	LUM isoform 1.	0.781
CIB1	MCM7	ENSPTRP00000012735	ENSPTRP00000033323	Calcium and integrin binding 1.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.810
CIB1	PTPRG	ENSPTRP00000012735	ENSPTRP00000026022	Calcium and integrin binding 1.	Protein tyrosine phosphatase, receptor type, G.	0.833
CIB1	THOP1	ENSPTRP00000012735	ENSPTRP00000057817	Calcium and integrin binding 1.	Thimet oligopeptidase 1.	0.823
CRADD	CIB1	ENSPTRP00000087931	ENSPTRP00000012735	CASP2 and RIPK1 domain containing adaptor with death domain.	Calcium and integrin binding 1.	0.774
CRADD	GPR37	ENSPTRP00000087931	ENSPTRP00000033642	CASP2 and RIPK1 domain containing adaptor with death domain.	G protein-coupled receptor 37.	0.844
CRADD	GRIN3A	ENSPTRP00000087931	ENSPTRP00000039833	CASP2 and RIPK1 domain containing adaptor with death domain.	GRIN3A isoform 1.	0.810
CRADD	LUM	ENSPTRP00000087931	ENSPTRP00000008987	CASP2 and RIPK1 domain containing adaptor with death domain.	LUM isoform 1.	0.827
CRADD	MCM7	ENSPTRP00000087931	ENSPTRP00000033323	CASP2 and RIPK1 domain containing adaptor with death domain.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.832
CRADD	PTPRG	ENSPTRP00000087931	ENSPTRP00000026022	CASP2 and RIPK1 domain containing adaptor with death domain.	Protein tyrosine phosphatase, receptor type, G.	0.816
CRADD	THOP1	ENSPTRP00000087931	ENSPTRP00000057817	CASP2 and RIPK1 domain containing adaptor with death domain.	Thimet oligopeptidase 1.	0.833
GPR37	CIB1	ENSPTRP00000033642	ENSPTRP00000012735	G protein-coupled receptor 37.	Calcium and integrin binding 1.	0.834
GPR37	CRADD	ENSPTRP00000033642	ENSPTRP00000087931	G protein-coupled receptor 37.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.844
GPR37	GRIN3A	ENSPTRP00000033642	ENSPTRP00000039833	G protein-coupled receptor 37.	GRIN3A isoform 1.	0.824