STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THOP1Thimet oligopeptidase 1. (517 aa)    
Predicted Functional Partners:
NTS
NTS isoform 1.
    
 0.859
PTPRG
Protein tyrosine phosphatase, receptor type, G.
   
 
 0.840
LGMN
LGMN isoform 1.
      
 0.806
GPR37
G protein-coupled receptor 37.
      
 0.805
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
      
 0.801
CHD6
Chromodomain helicase DNA binding protein 6.
    
 
 0.789
SPICE1
Spindle and centriole associated protein 1.
      
 0.784
ARHGEF1
Rho guanine nucleotide exchange factor 1.
      
 0.760
GRIN3A
GRIN3A isoform 1.
      
 0.756
NEDD9
Neural precursor cell expressed, developmentally down-regulated 9.
   
  
 0.746
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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