NOTCH4 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NOTCH4

NOTCH4 isoform 3. (2006 aa)

Predicted Functional Partners:

RBPJ

0.995

JAG1

0.993

DLL1

0.991

DLL3

0.979

MAML1

0.958

MAML2

0.957

RBPJL

0.956

PSEN1

0.951

MAML3

0.950

DLL4

0.949

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	DLL3	ENSPTRP00000032142	ENSPTRP00000063771	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta like canonical Notch ligand 3.	0.929
DLL1	DLL4	ENSPTRP00000032142	ENSPTRP00000070341	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.552
DLL1	JAG1	ENSPTRP00000032142	ENSPTRP00000022729	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.712
DLL1	MAML1	ENSPTRP00000032142	ENSPTRP00000056639	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	MAML1 isoform 1.	0.661
DLL1	MAML2	ENSPTRP00000032142	ENSPTRP00000007220	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.643
DLL1	MAML3	ENSPTRP00000032142	ENSPTRP00000079869	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	MAML3 isoform 1.	0.618
DLL1	NOTCH4	ENSPTRP00000032142	ENSPTRP00000059022	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH4 isoform 3.	0.991
DLL1	PSEN1	ENSPTRP00000032142	ENSPTRP00000011045	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.531
DLL1	RBPJ	ENSPTRP00000032142	ENSPTRP00000079413	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.825
DLL1	RBPJL	ENSPTRP00000032142	ENSPTRP00000023259	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region like.	0.471
DLL3	DLL1	ENSPTRP00000063771	ENSPTRP00000032142	Delta like canonical Notch ligand 3.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.929
DLL3	MAML1	ENSPTRP00000063771	ENSPTRP00000056639	Delta like canonical Notch ligand 3.	MAML1 isoform 1.	0.602
DLL3	MAML2	ENSPTRP00000063771	ENSPTRP00000007220	Delta like canonical Notch ligand 3.	Mastermind like transcriptional coactivator 2.	0.576
DLL3	MAML3	ENSPTRP00000063771	ENSPTRP00000079869	Delta like canonical Notch ligand 3.	MAML3 isoform 1.	0.567
DLL3	NOTCH4	ENSPTRP00000063771	ENSPTRP00000059022	Delta like canonical Notch ligand 3.	NOTCH4 isoform 3.	0.979
DLL3	RBPJ	ENSPTRP00000063771	ENSPTRP00000079413	Delta like canonical Notch ligand 3.	Recombination signal binding protein for immunoglobulin kappa J region.	0.569
DLL4	DLL1	ENSPTRP00000070341	ENSPTRP00000032142	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.552
DLL4	JAG1	ENSPTRP00000070341	ENSPTRP00000022729	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.579
DLL4	MAML1	ENSPTRP00000070341	ENSPTRP00000056639	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	MAML1 isoform 1.	0.673
DLL4	MAML2	ENSPTRP00000070341	ENSPTRP00000007220	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.642