HMGA1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK1	HMGA1	ENSPTRP00000050657	ENSPTRP00000075329	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	High mobility group protein HMG-I/HMG-Y.	0.652
CDK1	PARP1	ENSPTRP00000050657	ENSPTRP00000003457	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.439
CDK1	TP53	ENSPTRP00000050657	ENSPTRP00000014836	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.946
CK820_G0045089	HMGA1	ENSPTRP00000084713	ENSPTRP00000075329	RANBP3 isoform 23.	High mobility group protein HMG-I/HMG-Y.	0.606
CK820_G0045089	PARP1	ENSPTRP00000084713	ENSPTRP00000003457	RANBP3 isoform 23.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.698
CK820_G0045089	TP53	ENSPTRP00000084713	ENSPTRP00000014836	RANBP3 isoform 23.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.440
CYP4Z1	HMGA1	ENSPTRP00000001220	ENSPTRP00000075329	Cytochrome P450 family 4 subfamily Z member 1.	High mobility group protein HMG-I/HMG-Y.	0.663
CYP4Z1	TUSC2	ENSPTRP00000001220	ENSPTRP00000092216	Cytochrome P450 family 4 subfamily Z member 1.	Tumor suppressor 2, mitochondrial calcium regulator.	0.666
HMGA1	CDK1	ENSPTRP00000075329	ENSPTRP00000050657	High mobility group protein HMG-I/HMG-Y.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.652
HMGA1	CK820_G0045089	ENSPTRP00000075329	ENSPTRP00000084713	High mobility group protein HMG-I/HMG-Y.	RANBP3 isoform 23.	0.606
HMGA1	CYP4Z1	ENSPTRP00000075329	ENSPTRP00000001220	High mobility group protein HMG-I/HMG-Y.	Cytochrome P450 family 4 subfamily Z member 1.	0.663
HMGA1	HMGA2	ENSPTRP00000075329	ENSPTRP00000051717	High mobility group protein HMG-I/HMG-Y.	High mobility group AT-hook 2.	0.606
HMGA1	IL2RA	ENSPTRP00000075329	ENSPTRP00000003829	High mobility group protein HMG-I/HMG-Y.	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.	0.682
HMGA1	LOC462509	ENSPTRP00000075329	ENSPTRP00000085898	High mobility group protein HMG-I/HMG-Y.	HIST1H2BO isoform 1.	0.652
HMGA1	PARP1	ENSPTRP00000075329	ENSPTRP00000003457	High mobility group protein HMG-I/HMG-Y.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.622
HMGA1	PPARG	ENSPTRP00000075329	ENSPTRP00000076701	High mobility group protein HMG-I/HMG-Y.	Peroxisome proliferator-activated receptor gamma isoform X2.	0.666
HMGA1	TP53	ENSPTRP00000075329	ENSPTRP00000014836	High mobility group protein HMG-I/HMG-Y.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.631
HMGA1	TUSC2	ENSPTRP00000075329	ENSPTRP00000092216	High mobility group protein HMG-I/HMG-Y.	Tumor suppressor 2, mitochondrial calcium regulator.	0.706
HMGA2	HMGA1	ENSPTRP00000051717	ENSPTRP00000075329	High mobility group AT-hook 2.	High mobility group protein HMG-I/HMG-Y.	0.606
HMGA2	PARP1	ENSPTRP00000051717	ENSPTRP00000003457	High mobility group AT-hook 2.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.698