STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM124BFAM124B isoform 2. (455 aa)    
Predicted Functional Partners:
ICA1
Islet cell autoantigen 1.
      
 0.826
ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2.
      
 0.817
RPP38
Ribonuclease P/MRP 38kDa subunit.
      
 0.741
RPP38-2
Ribonuclease P/MRP subunit p38.
      
 0.741
PKP2
PKP2 isoform 1.
    
 0.708
CHD8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]
      
 0.648
LOC100608963
Zinc finger protein 254.
    
 0.617
CCDC157
CCDC157 isoform 1.
   
    0.522
ENSPTRP00000092784
annotation not available
    
 0.507
CHD7
CHD7 isoform 1.
      
 0.496
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.