| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACER1 | ACER3 | ENSPTRP00000017621 | ENSPTRP00000007035 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.428 |
| ACER1 | ASAH1 | ENSPTRP00000017621 | ENSPTRP00000063559 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | 0.963 |
| ACER1 | ASAH2 | ENSPTRP00000017621 | ENSPTRP00000090739 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Neutral ceramidase. | 0.954 |
| ACER1 | CERS1 | ENSPTRP00000017621 | ENSPTRP00000060390 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Ceramide synthase 1. | 0.933 |
| ACER1 | DEGS1 | ENSPTRP00000017621 | ENSPTRP00000003391 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Degenerative spermatocyte homolog 1, lipid desaturase. | 0.919 |
| ACER1 | DEGS2 | ENSPTRP00000017621 | ENSPTRP00000011449 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Delta 4-desaturase, sphingolipid 2. | 0.924 |
| ACER1 | PLPP2 | ENSPTRP00000017621 | ENSPTRP00000017230 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | PLPP2 isoform 5. | 0.921 |
| ACER1 | SGPP1 | ENSPTRP00000017621 | ENSPTRP00000010897 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingosine-1-phosphate phosphatase 1. | 0.915 |
| ACER1 | SGPP2 | ENSPTRP00000017621 | ENSPTRP00000078528 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingosine-1-phosphate phosphatase 2. | 0.915 |
| ACER3 | ACER1 | ENSPTRP00000007035 | ENSPTRP00000017621 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.428 |
| ACER3 | ASAH1 | ENSPTRP00000007035 | ENSPTRP00000063559 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | 0.970 |
| ACER3 | ASAH2 | ENSPTRP00000007035 | ENSPTRP00000090739 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Neutral ceramidase. | 0.960 |
| ACER3 | CERS1 | ENSPTRP00000007035 | ENSPTRP00000060390 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Ceramide synthase 1. | 0.955 |
| ACER3 | DEGS1 | ENSPTRP00000007035 | ENSPTRP00000003391 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Degenerative spermatocyte homolog 1, lipid desaturase. | 0.941 |
| ACER3 | DEGS2 | ENSPTRP00000007035 | ENSPTRP00000011449 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Delta 4-desaturase, sphingolipid 2. | 0.955 |
| ACER3 | KDSR | ENSPTRP00000007035 | ENSPTRP00000017122 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.935 |
| ACER3 | PLPP2 | ENSPTRP00000007035 | ENSPTRP00000017230 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | PLPP2 isoform 5. | 0.953 |
| ACER3 | SGPP1 | ENSPTRP00000007035 | ENSPTRP00000010897 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingosine-1-phosphate phosphatase 1. | 0.937 |
| ACER3 | SGPP2 | ENSPTRP00000007035 | ENSPTRP00000078528 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingosine-1-phosphate phosphatase 2. | 0.945 |
| ASAH1 | ACER1 | ENSPTRP00000063559 | ENSPTRP00000017621 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.963 |
