STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD70CD70 isoform 1; Belongs to the tumor necrosis factor family. (208 aa)    
Predicted Functional Partners:
CD27
CD27 isoform 1.
    
 0.999
CD40LG
CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
      
 0.876
TNFRSF4
TNFRSF4 isoform 2.
   
  
 0.857
TNFRSF9
TNF receptor superfamily member 9.
      
 0.797
CD28
CD28 isoform 3.
      
 0.794
TNFSF9
TNF superfamily member 9; Belongs to the tumor necrosis factor family.
   
  
 0.757
TNFRSF8
TNF receptor superfamily member 8.
   
  
 0.756
ICOS
Inducible T cell costimulator.
      
 0.745
CD80
CD80 isoform 1.
      
 0.687
CD86
CD86 isoform 3.
  
   
 0.684
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.