PTPN11 protein (Pan troglodytes) - STRING interaction network

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Score

PTPN11

Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)

Predicted Functional Partners:

GRB2

0.999

SOS1

0.995

GAB1

0.994

EGFR

0.994

IRS1

0.993

PDGFRB

0.991

PIK3R1

0.986

PECAM1

0.983

JAK1

0.979

PDCD1

0.978

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	GAB1	ENSPTRP00000069741	ENSPTRP00000028277	Receptor protein-tyrosine kinase.	GRB2-associated-binding protein 1.	0.997
EGFR	GRB2	ENSPTRP00000069741	ENSPTRP00000016382	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2.	0.999
EGFR	IRS1	ENSPTRP00000069741	ENSPTRP00000022194	Receptor protein-tyrosine kinase.	Insulin receptor substrate 1.	0.861
EGFR	JAK1	ENSPTRP00000069741	ENSPTRP00000001425	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.953
EGFR	PDCD1	ENSPTRP00000069741	ENSPTRP00000080804	Receptor protein-tyrosine kinase.	Programmed cell death 1.	0.550
EGFR	PDGFRB	ENSPTRP00000069741	ENSPTRP00000080188	Receptor protein-tyrosine kinase.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.985
EGFR	PECAM1	ENSPTRP00000069741	ENSPTRP00000080846	Receptor protein-tyrosine kinase.	Platelet/endothelial cell adhesion molecule.	0.529
EGFR	PIK3R1	ENSPTRP00000069741	ENSPTRP00000076964	Receptor protein-tyrosine kinase.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).	0.996
EGFR	PTPN11	ENSPTRP00000069741	ENSPTRP00000061336	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.994
EGFR	SOS1	ENSPTRP00000069741	ENSPTRP00000052023	Receptor protein-tyrosine kinase.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.999
GAB1	EGFR	ENSPTRP00000028277	ENSPTRP00000069741	GRB2-associated-binding protein 1.	Receptor protein-tyrosine kinase.	0.997
GAB1	GRB2	ENSPTRP00000028277	ENSPTRP00000016382	GRB2-associated-binding protein 1.	Growth factor receptor-bound protein 2.	0.999
GAB1	IRS1	ENSPTRP00000028277	ENSPTRP00000022194	GRB2-associated-binding protein 1.	Insulin receptor substrate 1.	0.640
GAB1	PDGFRB	ENSPTRP00000028277	ENSPTRP00000080188	GRB2-associated-binding protein 1.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.934
GAB1	PIK3R1	ENSPTRP00000028277	ENSPTRP00000076964	GRB2-associated-binding protein 1.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).	0.990
GAB1	PTPN11	ENSPTRP00000028277	ENSPTRP00000061336	GRB2-associated-binding protein 1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.994
GAB1	SOS1	ENSPTRP00000028277	ENSPTRP00000052023	GRB2-associated-binding protein 1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.976
GRB2	EGFR	ENSPTRP00000016382	ENSPTRP00000069741	Growth factor receptor-bound protein 2.	Receptor protein-tyrosine kinase.	0.999
GRB2	GAB1	ENSPTRP00000016382	ENSPTRP00000028277	Growth factor receptor-bound protein 2.	GRB2-associated-binding protein 1.	0.999
GRB2	IRS1	ENSPTRP00000016382	ENSPTRP00000022194	Growth factor receptor-bound protein 2.	Insulin receptor substrate 1.	0.998