PTPN11 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	GAB1	ENSPTRP00000069741	ENSPTRP00000028277	Receptor protein-tyrosine kinase.	GRB2-associated-binding protein 1.	0.996
EGFR	GRB2	ENSPTRP00000069741	ENSPTRP00000016382	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2.	0.999
EGFR	JAK1	ENSPTRP00000069741	ENSPTRP00000001425	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.969
EGFR	JAK2	ENSPTRP00000069741	ENSPTRP00000082180	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.986
EGFR	PDGFRB	ENSPTRP00000069741	ENSPTRP00000080188	Receptor protein-tyrosine kinase.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.978
EGFR	PIK3CA	ENSPTRP00000069741	ENSPTRP00000084763	Receptor protein-tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.997
EGFR	PIK3R1	ENSPTRP00000069741	ENSPTRP00000076964	Receptor protein-tyrosine kinase.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).	0.997
EGFR	PTPN11	ENSPTRP00000069741	ENSPTRP00000061336	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.985
EGFR	SOS1	ENSPTRP00000069741	ENSPTRP00000052023	Receptor protein-tyrosine kinase.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.997
GAB1	EGFR	ENSPTRP00000028277	ENSPTRP00000069741	GRB2-associated-binding protein 1.	Receptor protein-tyrosine kinase.	0.996
GAB1	GRB2	ENSPTRP00000028277	ENSPTRP00000016382	GRB2-associated-binding protein 1.	Growth factor receptor-bound protein 2.	0.999
GAB1	JAK1	ENSPTRP00000028277	ENSPTRP00000001425	GRB2-associated-binding protein 1.	Tyrosine-protein kinase.	0.457
GAB1	JAK2	ENSPTRP00000028277	ENSPTRP00000082180	GRB2-associated-binding protein 1.	Tyrosine-protein kinase.	0.561
GAB1	PDGFRB	ENSPTRP00000028277	ENSPTRP00000080188	GRB2-associated-binding protein 1.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.927
GAB1	PIK3CA	ENSPTRP00000028277	ENSPTRP00000084763	GRB2-associated-binding protein 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.980
GAB1	PIK3R1	ENSPTRP00000028277	ENSPTRP00000076964	GRB2-associated-binding protein 1.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).	0.996
GAB1	PTPN11	ENSPTRP00000028277	ENSPTRP00000061336	GRB2-associated-binding protein 1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.985
GAB1	SOS1	ENSPTRP00000028277	ENSPTRP00000052023	GRB2-associated-binding protein 1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.975
GRB2	EGFR	ENSPTRP00000016382	ENSPTRP00000069741	Growth factor receptor-bound protein 2.	Receptor protein-tyrosine kinase.	0.999
GRB2	GAB1	ENSPTRP00000016382	ENSPTRP00000028277	Growth factor receptor-bound protein 2.	GRB2-associated-binding protein 1.	0.999