RAPGEF4 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC8	RAPGEF3	ENSPTRP00000048225	ENSPTRP00000008316	ABCC8 isoform 2.	Rap guanine nucleotide exchange factor 3.	0.903
ABCC8	RAPGEF4	ENSPTRP00000048225	ENSPTRP00000062019	ABCC8 isoform 2.	RAPGEF4 isoform 2.	0.995
ADCY7	ADCY8	ENSPTRP00000062799	ENSPTRP00000077396	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.557
ADCY7	RAPGEF3	ENSPTRP00000062799	ENSPTRP00000008316	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Rap guanine nucleotide exchange factor 3.	0.914
ADCY7	RAPGEF4	ENSPTRP00000062799	ENSPTRP00000062019	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	RAPGEF4 isoform 2.	0.948
ADCY8	ADCY7	ENSPTRP00000077396	ENSPTRP00000062799	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.557
ADCY8	RAPGEF3	ENSPTRP00000077396	ENSPTRP00000008316	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Rap guanine nucleotide exchange factor 3.	0.942
ADCY8	RAPGEF4	ENSPTRP00000077396	ENSPTRP00000062019	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	RAPGEF4 isoform 2.	0.952
MAPK8	RAP1A	ENSPTRP00000040692	ENSPTRP00000084644	Mitogen-activated protein kinase.	RAP1A, member of RAS oncogene family.	0.926
MAPK8	RAP1B	ENSPTRP00000040692	ENSPTRP00000070769	Mitogen-activated protein kinase.	Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family.	0.926
MAPK8	RAPGEF3	ENSPTRP00000040692	ENSPTRP00000008316	Mitogen-activated protein kinase.	Rap guanine nucleotide exchange factor 3.	0.903
MAPK8	RAPGEF4	ENSPTRP00000040692	ENSPTRP00000062019	Mitogen-activated protein kinase.	RAPGEF4 isoform 2.	0.949
PCLO	RAPGEF4	ENSPTRP00000064584	ENSPTRP00000062019	Piccolo presynaptic cytomatrix protein.	RAPGEF4 isoform 2.	0.958
RAP1A	MAPK8	ENSPTRP00000084644	ENSPTRP00000040692	RAP1A, member of RAS oncogene family.	Mitogen-activated protein kinase.	0.926
RAP1A	RAP1B	ENSPTRP00000084644	ENSPTRP00000070769	RAP1A, member of RAS oncogene family.	Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family.	0.996
RAP1A	RAPGEF3	ENSPTRP00000084644	ENSPTRP00000008316	RAP1A, member of RAS oncogene family.	Rap guanine nucleotide exchange factor 3.	0.988
RAP1A	RAPGEF4	ENSPTRP00000084644	ENSPTRP00000062019	RAP1A, member of RAS oncogene family.	RAPGEF4 isoform 2.	0.994
RAP1B	MAPK8	ENSPTRP00000070769	ENSPTRP00000040692	Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family.	Mitogen-activated protein kinase.	0.926
RAP1B	RAP1A	ENSPTRP00000070769	ENSPTRP00000084644	Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family.	RAP1A, member of RAS oncogene family.	0.996
RAP1B	RAPGEF3	ENSPTRP00000070769	ENSPTRP00000008316	Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family.	Rap guanine nucleotide exchange factor 3.	0.981