SYNGAP1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKS1B	DLG4	ENSPTRP00000045687	ENSPTRP00000014780	Ankyrin repeat and sterile alpha motif domain containing 1B.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.823
ANKS1B	DLGAP3	ENSPTRP00000045687	ENSPTRP00000043508	Ankyrin repeat and sterile alpha motif domain containing 1B.	DLG associated protein 3.	0.456
ANKS1B	GRIN1	ENSPTRP00000045687	ENSPTRP00000041565	Ankyrin repeat and sterile alpha motif domain containing 1B.	Glutamate receptor, ionotropic, N-methyl D-aspartate 1.	0.797
ANKS1B	GRIN2B	ENSPTRP00000045687	ENSPTRP00000008060	Ankyrin repeat and sterile alpha motif domain containing 1B.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.462
ANKS1B	SYNGAP1	ENSPTRP00000045687	ENSPTRP00000062076	Ankyrin repeat and sterile alpha motif domain containing 1B.	Synaptic Ras GTPase activating protein 1.	0.949
DLG3	DLG4	ENSPTRP00000069805	ENSPTRP00000014780	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.992
DLG3	DLGAP2	ENSPTRP00000069805	ENSPTRP00000042538	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	DLGAP2 isoform 1.	0.914
DLG3	DLGAP3	ENSPTRP00000069805	ENSPTRP00000043508	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	DLG associated protein 3.	0.829
DLG3	GRIN1	ENSPTRP00000069805	ENSPTRP00000041565	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Glutamate receptor, ionotropic, N-methyl D-aspartate 1.	0.922
DLG3	GRIN2A	ENSPTRP00000069805	ENSPTRP00000055315	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Glutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...]	0.964
DLG3	GRIN2B	ENSPTRP00000069805	ENSPTRP00000008060	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.983
DLG3	HOMER1	ENSPTRP00000069805	ENSPTRP00000084197	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	HOMER1 isoform 1.	0.616
DLG3	SHANK2	ENSPTRP00000069805	ENSPTRP00000006892	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	SH3 and multiple ankyrin repeat domains 2.	0.807
DLG3	SYNGAP1	ENSPTRP00000069805	ENSPTRP00000062076	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Synaptic Ras GTPase activating protein 1.	0.821
DLG4	ANKS1B	ENSPTRP00000014780	ENSPTRP00000045687	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Ankyrin repeat and sterile alpha motif domain containing 1B.	0.823
DLG4	DLG3	ENSPTRP00000014780	ENSPTRP00000069805	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	0.992
DLG4	DLGAP2	ENSPTRP00000014780	ENSPTRP00000042538	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	DLGAP2 isoform 1.	0.877
DLG4	DLGAP3	ENSPTRP00000014780	ENSPTRP00000043508	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	DLG associated protein 3.	0.950
DLG4	GRIN1	ENSPTRP00000014780	ENSPTRP00000041565	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Glutamate receptor, ionotropic, N-methyl D-aspartate 1.	0.998
DLG4	GRIN2A	ENSPTRP00000014780	ENSPTRP00000055315	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Glutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...]	0.997