node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FADD | IRAK4 | ENSPTRP00000006883 | ENSPTRP00000008285 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Interleukin-1 receptor-associated kinase 4. | 0.403 |
FADD | LY96 | ENSPTRP00000006883 | ENSPTRP00000083213 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Lymphocyte antigen 96. | 0.504 |
FADD | MYD88 | ENSPTRP00000006883 | ENSPTRP00000061524 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.975 |
FADD | TIRAP | ENSPTRP00000006883 | ENSPTRP00000063957 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. | 0.920 |
FADD | TLR3 | ENSPTRP00000006883 | ENSPTRP00000028569 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Toll-like receptor 3; Belongs to the Toll-like receptor family. | 0.592 |
FADD | TLR4 | ENSPTRP00000006883 | ENSPTRP00000036398 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.673 |
FADD | TRAF6 | ENSPTRP00000006883 | ENSPTRP00000006096 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.757 |
IRAK4 | FADD | ENSPTRP00000008285 | ENSPTRP00000006883 | Interleukin-1 receptor-associated kinase 4. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.403 |
IRAK4 | LY96 | ENSPTRP00000008285 | ENSPTRP00000083213 | Interleukin-1 receptor-associated kinase 4. | Lymphocyte antigen 96. | 0.578 |
IRAK4 | MYD88 | ENSPTRP00000008285 | ENSPTRP00000061524 | Interleukin-1 receptor-associated kinase 4. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.999 |
IRAK4 | TIRAP | ENSPTRP00000008285 | ENSPTRP00000063957 | Interleukin-1 receptor-associated kinase 4. | Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. | 0.984 |
IRAK4 | TLR2 | ENSPTRP00000008285 | ENSPTRP00000028379 | Interleukin-1 receptor-associated kinase 4. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.801 |
IRAK4 | TLR3 | ENSPTRP00000008285 | ENSPTRP00000028569 | Interleukin-1 receptor-associated kinase 4. | Toll-like receptor 3; Belongs to the Toll-like receptor family. | 0.779 |
IRAK4 | TLR4 | ENSPTRP00000008285 | ENSPTRP00000036398 | Interleukin-1 receptor-associated kinase 4. | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.981 |
IRAK4 | TLR9 | ENSPTRP00000008285 | ENSPTRP00000083908 | Interleukin-1 receptor-associated kinase 4. | T0016681 isoform 1. | 0.825 |
IRAK4 | TOLLIP | ENSPTRP00000008285 | ENSPTRP00000083767 | Interleukin-1 receptor-associated kinase 4. | Toll interacting protein. | 0.959 |
IRAK4 | TRAF6 | ENSPTRP00000008285 | ENSPTRP00000006096 | Interleukin-1 receptor-associated kinase 4. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.999 |
LY96 | FADD | ENSPTRP00000083213 | ENSPTRP00000006883 | Lymphocyte antigen 96. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.504 |
LY96 | IRAK4 | ENSPTRP00000083213 | ENSPTRP00000008285 | Lymphocyte antigen 96. | Interleukin-1 receptor-associated kinase 4. | 0.578 |
LY96 | MYD88 | ENSPTRP00000083213 | ENSPTRP00000061524 | Lymphocyte antigen 96. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.990 |