| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASAH1 | ASAH2 | ENSPTRP00000063559 | ENSPTRP00000090739 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Neutral ceramidase. | 0.956 |
| ASAH1 | CERK | ENSPTRP00000063559 | ENSPTRP00000087585 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Ceramide kinase. | 0.958 |
| ASAH1 | GBA | ENSPTRP00000063559 | ENSPTRP00000051730 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | 0.944 |
| ASAH1 | GBA2 | ENSPTRP00000063559 | ENSPTRP00000035782 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | 0.957 |
| ASAH1 | SGMS1 | ENSPTRP00000063559 | ENSPTRP00000004317 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Sphingomyelin synthase 1. | 0.940 |
| ASAH1 | SGMS2 | ENSPTRP00000063559 | ENSPTRP00000065895 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Sphingomyelin synthase 2. | 0.943 |
| ASAH1 | SMPD2 | ENSPTRP00000063559 | ENSPTRP00000031570 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Sphingomyelin phosphodiesterase 2, neutral membrane (Neutral sphingomyelinase). | 0.946 |
| ASAH1 | UGCG | ENSPTRP00000063559 | ENSPTRP00000065363 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | UDP-glucose ceramide glucosyltransferase. | 0.947 |
| ASAH2 | ASAH1 | ENSPTRP00000090739 | ENSPTRP00000063559 | Neutral ceramidase. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | 0.956 |
| ASAH2 | CERK | ENSPTRP00000090739 | ENSPTRP00000087585 | Neutral ceramidase. | Ceramide kinase. | 0.963 |
| ASAH2 | GBA | ENSPTRP00000090739 | ENSPTRP00000051730 | Neutral ceramidase. | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | 0.911 |
| ASAH2 | GBA2 | ENSPTRP00000090739 | ENSPTRP00000035782 | Neutral ceramidase. | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | 0.945 |
| ASAH2 | SGMS1 | ENSPTRP00000090739 | ENSPTRP00000004317 | Neutral ceramidase. | Sphingomyelin synthase 1. | 0.940 |
| ASAH2 | SGMS2 | ENSPTRP00000090739 | ENSPTRP00000065895 | Neutral ceramidase. | Sphingomyelin synthase 2. | 0.944 |
| ASAH2 | SMPD2 | ENSPTRP00000090739 | ENSPTRP00000031570 | Neutral ceramidase. | Sphingomyelin phosphodiesterase 2, neutral membrane (Neutral sphingomyelinase). | 0.947 |
| ASAH2 | UGCG | ENSPTRP00000090739 | ENSPTRP00000065363 | Neutral ceramidase. | UDP-glucose ceramide glucosyltransferase. | 0.952 |
| B4GALT5 | B4GALT6 | ENSPTRP00000023410 | ENSPTRP00000016918 | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5. | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6. | 0.992 |
| B4GALT5 | GBA | ENSPTRP00000023410 | ENSPTRP00000051730 | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5. | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | 0.909 |
| B4GALT5 | GBA2 | ENSPTRP00000023410 | ENSPTRP00000035782 | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5. | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | 0.919 |
| B4GALT5 | UGCG | ENSPTRP00000023410 | ENSPTRP00000065363 | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5. | UDP-glucose ceramide glucosyltransferase. | 0.950 |
