HRH2 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP12A	GAST	ENSPTRP00000009734	ENSPTRP00000015628	Sodium/potassium-transporting ATPase subunit alpha.	GAST isoform 1.	0.619
ATP12A	HRH2	ENSPTRP00000009734	ENSPTRP00000067391	Sodium/potassium-transporting ATPase subunit alpha.	Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity); Belongs to the G-protein coupled receptor 1 family.	0.613
GAST	ATP12A	ENSPTRP00000015628	ENSPTRP00000009734	GAST isoform 1.	Sodium/potassium-transporting ATPase subunit alpha.	0.619
GAST	GNB1	ENSPTRP00000015628	ENSPTRP00000067330	GAST isoform 1.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.675
GAST	GNG2	ENSPTRP00000015628	ENSPTRP00000065345	GAST isoform 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.606
GAST	HDC	ENSPTRP00000015628	ENSPTRP00000012071	GAST isoform 1.	Histidine decarboxylase.	0.495
GAST	HRH2	ENSPTRP00000015628	ENSPTRP00000067391	GAST isoform 1.	Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity); Belongs to the G-protein coupled receptor 1 family.	0.615
GNAL	GNAS	ENSPTRP00000077082	ENSPTRP00000059419	G protein subunit alpha L.	GNAS isoform 19.	0.981
GNAL	GNB1	ENSPTRP00000077082	ENSPTRP00000067330	G protein subunit alpha L.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.986
GNAL	GNG2	ENSPTRP00000077082	ENSPTRP00000065345	G protein subunit alpha L.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.750
GNAL	HRH2	ENSPTRP00000077082	ENSPTRP00000067391	G protein subunit alpha L.	Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity); Belongs to the G-protein coupled receptor 1 family.	0.782
GNAL	LOC104003639	ENSPTRP00000077082	ENSPTRP00000063078	G protein subunit alpha L.	Guanine nucleotide-binding protein G(s) subunit alpha.	0.902
GNAS	GNAL	ENSPTRP00000059419	ENSPTRP00000077082	GNAS isoform 19.	G protein subunit alpha L.	0.981
GNAS	GNB1	ENSPTRP00000059419	ENSPTRP00000067330	GNAS isoform 19.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.996
GNAS	GNG2	ENSPTRP00000059419	ENSPTRP00000065345	GNAS isoform 19.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.995
GNAS	HRH2	ENSPTRP00000059419	ENSPTRP00000067391	GNAS isoform 19.	Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity); Belongs to the G-protein coupled receptor 1 family.	0.946
GNAS	LOC104003639	ENSPTRP00000059419	ENSPTRP00000063078	GNAS isoform 19.	Guanine nucleotide-binding protein G(s) subunit alpha.	0.951
GNB1	GAST	ENSPTRP00000067330	ENSPTRP00000015628	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	GAST isoform 1.	0.675
GNB1	GNAL	ENSPTRP00000067330	ENSPTRP00000077082	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	G protein subunit alpha L.	0.986
GNB1	GNAS	ENSPTRP00000067330	ENSPTRP00000059419	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	GNAS isoform 19.	0.996