| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CK820_G0054574 | HERC4 | ENSPTRP00000046998 | ENSPTRP00000067696 | ISG15 isoform 1. | Hect domain and RLD 4. | 0.635 |
| CK820_G0054574 | UBA1 | ENSPTRP00000046998 | ENSPTRP00000065814 | ISG15 isoform 1. | UBA1 isoform 3; Belongs to the ubiquitin-activating E1 family. | 0.914 |
| FAM13A | HERC4 | ENSPTRP00000027960 | ENSPTRP00000067696 | Family with sequence similarity 13, member A. | Hect domain and RLD 4. | 0.746 |
| FAM13A | LOC107973888 | ENSPTRP00000027960 | ENSPTRP00000059954 | Family with sequence similarity 13, member A. | Phosphatidylinositol glycan anchor biosynthesis, class Y. | 0.907 |
| FAM13A | MYPN | ENSPTRP00000027960 | ENSPTRP00000046961 | Family with sequence similarity 13, member A. | MYPN isoform 1. | 0.742 |
| HERC4 | CK820_G0054574 | ENSPTRP00000067696 | ENSPTRP00000046998 | Hect domain and RLD 4. | ISG15 isoform 1. | 0.635 |
| HERC4 | FAM13A | ENSPTRP00000067696 | ENSPTRP00000027960 | Hect domain and RLD 4. | Family with sequence similarity 13, member A. | 0.746 |
| HERC4 | IFT88 | ENSPTRP00000067696 | ENSPTRP00000045992 | Hect domain and RLD 4. | Intraflagellar transport 88. | 0.635 |
| HERC4 | ISG15 | ENSPTRP00000067696 | ENSPTRP00000060878 | Hect domain and RLD 4. | ISG15 ubiquitin-like modifier. | 0.700 |
| HERC4 | LOC107973888 | ENSPTRP00000067696 | ENSPTRP00000059954 | Hect domain and RLD 4. | Phosphatidylinositol glycan anchor biosynthesis, class Y. | 0.739 |
| HERC4 | MYPN | ENSPTRP00000067696 | ENSPTRP00000046961 | Hect domain and RLD 4. | MYPN isoform 1. | 0.698 |
| HERC4 | PDE6D | ENSPTRP00000067696 | ENSPTRP00000022277 | Hect domain and RLD 4. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] | 0.743 |
| HERC4 | RPGRIP1 | ENSPTRP00000067696 | ENSPTRP00000073611 | Hect domain and RLD 4. | RPGR interacting protein 1. | 0.612 |
| HERC4 | TRIM5 | ENSPTRP00000067696 | ENSPTRP00000005730 | Hect domain and RLD 4. | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] | 0.625 |
| HERC4 | UBA1 | ENSPTRP00000067696 | ENSPTRP00000065814 | Hect domain and RLD 4. | UBA1 isoform 3; Belongs to the ubiquitin-activating E1 family. | 0.621 |
| IFT88 | HERC4 | ENSPTRP00000045992 | ENSPTRP00000067696 | Intraflagellar transport 88. | Hect domain and RLD 4. | 0.635 |
| IFT88 | PDE6D | ENSPTRP00000045992 | ENSPTRP00000022277 | Intraflagellar transport 88. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] | 0.687 |
| IFT88 | RPGRIP1 | ENSPTRP00000045992 | ENSPTRP00000073611 | Intraflagellar transport 88. | RPGR interacting protein 1. | 0.761 |
| ISG15 | HERC4 | ENSPTRP00000060878 | ENSPTRP00000067696 | ISG15 ubiquitin-like modifier. | Hect domain and RLD 4. | 0.700 |
| ISG15 | TRIM5 | ENSPTRP00000060878 | ENSPTRP00000005730 | ISG15 ubiquitin-like modifier. | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] | 0.427 |
