Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IL23RIL23R isoform 1. (629 aa)    
Predicted Functional Partners:
JAK2
Tyrosine-protein kinase.
    
 0.997
IL23A
Interleukin 23 subunit alpha.
    
 0.995
IL12RB1
IL12RB1 isoform 1.
    
 0.995
STAT3
Signal transducer and activator of transcription.
   
 0.993
IL12B
Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
   
 0.990
STAT4
Signal transducer and activator of transcription.
   
 0.982
TYK2
Tyrosine-protein kinase.
    
 0.968
IL12A
Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
     
 0.927
JAK1
Tyrosine-protein kinase.
    
 0.921
IL12RB2
Interleukin 12 receptor subunit beta 2.
     
0.910
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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