HSP90AA1 protein (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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gene co-occurrence

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Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHR	HSP90AA1	ENSPTRP00000032381	ENSPTRP00000070946	T0073207 isoform 1.	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.984
AHR	HSP90AB1	ENSPTRP00000032381	ENSPTRP00000031135	T0073207 isoform 1.	HSP90AB1 isoform 1.	0.976
AHR	LOC461365	ENSPTRP00000032381	ENSPTRP00000093883	T0073207 isoform 1.	Heat shock protein HSP 90-beta pseudogene.	0.810
AKT1	AR	ENSPTRP00000082849	ENSPTRP00000076864	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.864
AKT1	CDC37	ENSPTRP00000082849	ENSPTRP00000017839	AKT1 isoform 3; Belongs to the protein kinase superfamily.	CDC37 isoform 2.	0.986
AKT1	CDC37-2	ENSPTRP00000082849	ENSPTRP00000078192	AKT1 isoform 3; Belongs to the protein kinase superfamily.	LOW QUALITY PROTEIN: hsp90 co-chaperone Cdc37.	0.979
AKT1	HSP90AA1	ENSPTRP00000082849	ENSPTRP00000070946	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.997
AKT1	HSP90AB1	ENSPTRP00000082849	ENSPTRP00000031135	AKT1 isoform 3; Belongs to the protein kinase superfamily.	HSP90AB1 isoform 1.	0.988
AKT1	HSPA4	ENSPTRP00000082849	ENSPTRP00000029477	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Heat shock protein family A (Hsp70) member 4.	0.523
AKT1	LOC461365	ENSPTRP00000082849	ENSPTRP00000093883	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Heat shock protein HSP 90-beta pseudogene.	0.818
AKT1	NOS3	ENSPTRP00000082849	ENSPTRP00000034022	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.998
AR	AKT1	ENSPTRP00000076864	ENSPTRP00000082849	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	AKT1 isoform 3; Belongs to the protein kinase superfamily.	0.864
AR	HSP90AA1	ENSPTRP00000076864	ENSPTRP00000070946	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.995
AR	HSP90AB1	ENSPTRP00000076864	ENSPTRP00000031135	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	HSP90AB1 isoform 1.	0.982
AR	HSPA4	ENSPTRP00000076864	ENSPTRP00000029477	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Heat shock protein family A (Hsp70) member 4.	0.660
AR	LOC461365	ENSPTRP00000076864	ENSPTRP00000093883	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Heat shock protein HSP 90-beta pseudogene.	0.768
CDC37	AKT1	ENSPTRP00000017839	ENSPTRP00000082849	CDC37 isoform 2.	AKT1 isoform 3; Belongs to the protein kinase superfamily.	0.986
CDC37	CDC37-2	ENSPTRP00000017839	ENSPTRP00000078192	CDC37 isoform 2.	LOW QUALITY PROTEIN: hsp90 co-chaperone Cdc37.	0.900
CDC37	HSP90AA1	ENSPTRP00000017839	ENSPTRP00000070946	CDC37 isoform 2.	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.996
CDC37	HSP90AB1	ENSPTRP00000017839	ENSPTRP00000031135	CDC37 isoform 2.	HSP90AB1 isoform 1.	0.996