INSRR protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRB2	IGF1	ENSPTRP00000016382	ENSPTRP00000067917	Growth factor receptor-bound protein 2.	Insulin-like growth factor 1 (Somatomedin C).	0.595
GRB2	IGF1R	ENSPTRP00000016382	ENSPTRP00000012792	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase receptor.	0.974
GRB2	INS	ENSPTRP00000016382	ENSPTRP00000077843	Growth factor receptor-bound protein 2.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.713
GRB2	INSRR	ENSPTRP00000016382	ENSPTRP00000071850	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase receptor.	0.954
GRB2	PIK3CA	ENSPTRP00000016382	ENSPTRP00000084763	Growth factor receptor-bound protein 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.958
GRB2	PIK3R1	ENSPTRP00000016382	ENSPTRP00000076964	Growth factor receptor-bound protein 2.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).	0.974
GRB2	PIK3R3	ENSPTRP00000016382	ENSPTRP00000063975	Growth factor receptor-bound protein 2.	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma).	0.846
GRB2	PTPN1	ENSPTRP00000016382	ENSPTRP00000043532	Growth factor receptor-bound protein 2.	Tyrosine-protein phosphatase non-receptor type.	0.810
GRB2	SOS1	ENSPTRP00000016382	ENSPTRP00000052023	Growth factor receptor-bound protein 2.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.999
GRB2	SOS2	ENSPTRP00000016382	ENSPTRP00000043790	Growth factor receptor-bound protein 2.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.999
IGF1	GRB2	ENSPTRP00000067917	ENSPTRP00000016382	Insulin-like growth factor 1 (Somatomedin C).	Growth factor receptor-bound protein 2.	0.595
IGF1	IGF1R	ENSPTRP00000067917	ENSPTRP00000012792	Insulin-like growth factor 1 (Somatomedin C).	Tyrosine-protein kinase receptor.	0.999
IGF1	INS	ENSPTRP00000067917	ENSPTRP00000077843	Insulin-like growth factor 1 (Somatomedin C).	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.985
IGF1	INSRR	ENSPTRP00000067917	ENSPTRP00000071850	Insulin-like growth factor 1 (Somatomedin C).	Tyrosine-protein kinase receptor.	0.921
IGF1	PIK3CA	ENSPTRP00000067917	ENSPTRP00000084763	Insulin-like growth factor 1 (Somatomedin C).	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.602
IGF1	PIK3R1	ENSPTRP00000067917	ENSPTRP00000076964	Insulin-like growth factor 1 (Somatomedin C).	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).	0.469
IGF1	SOS1	ENSPTRP00000067917	ENSPTRP00000052023	Insulin-like growth factor 1 (Somatomedin C).	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.503
IGF1	SOS2	ENSPTRP00000067917	ENSPTRP00000043790	Insulin-like growth factor 1 (Somatomedin C).	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.407
IGF1R	GRB2	ENSPTRP00000012792	ENSPTRP00000016382	Tyrosine-protein kinase receptor.	Growth factor receptor-bound protein 2.	0.974
IGF1R	IGF1	ENSPTRP00000012792	ENSPTRP00000067917	Tyrosine-protein kinase receptor.	Insulin-like growth factor 1 (Somatomedin C).	0.999