Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CDKL1Cyclin-dependent kinase-like 1 (CDC2-related kinase); Belongs to the protein kinase superfamily. (358 aa)    
Predicted Functional Partners:
CDKL3
Cyclin dependent kinase like 3.
   
    0.922
CDKL2
Cyclin dependent kinase like 2.
   
    0.849
CDKL4
CDKL4 isoform 1.
    
   0.810
YWHAB
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.
      
 0.764
FKBP5
Peptidylprolyl isomerase.
   
   0.636
MCL1
Myeloid cell leukemia sequence 1 (BCL2-related).
      
 0.592
YWHAG
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Belongs to the 14-3-3 family.
      
 0.553
SIRT1
SIRT1 isoform 2.
    
 
 0.550
SIRT1-2
Sirtuin 1.
    
 
 0.550
PCDHB1
Protocadherin beta-1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
      
 0.523
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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