| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DDIT3 | GUF1 | ENSPTRP00000043666 | ENSPTRP00000073050 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | 0.666 |
| GUF1 | DDIT3 | ENSPTRP00000073050 | ENSPTRP00000043666 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] | 0.666 |
| GUF1 | KCNIP1 | ENSPTRP00000073050 | ENSPTRP00000088927 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | Potassium voltage-gated channel interacting protein 1. | 0.740 |
| GUF1 | KCNIP3 | ENSPTRP00000073050 | ENSPTRP00000020937 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | Potassium voltage-gated channel interacting protein 3. | 0.653 |
| GUF1 | MRPL19 | ENSPTRP00000073050 | ENSPTRP00000020776 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | Mitochondrial ribosomal protein L19. | 0.652 |
| GUF1 | MRPL20 | ENSPTRP00000073050 | ENSPTRP00000086537 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | Mitochondrial ribosomal protein L20. | 0.671 |
| GUF1 | MRPL27 | ENSPTRP00000073050 | ENSPTRP00000015958 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | Mitochondrial ribosomal protein L27. | 0.645 |
| GUF1 | MRPL32 | ENSPTRP00000073050 | ENSPTRP00000032659 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | Mitochondrial ribosomal protein L32. | 0.664 |
| GUF1 | MRPS6 | ENSPTRP00000073050 | ENSPTRP00000023883 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | Mitochondrial ribosomal protein S6. | 0.679 |
| GUF1 | MRPS9 | ENSPTRP00000073050 | ENSPTRP00000021085 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | Mitochondrial ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. | 0.676 |
| GUF1 | RRM1 | ENSPTRP00000073050 | ENSPTRP00000005668 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.708 |
| KCNIP1 | GUF1 | ENSPTRP00000088927 | ENSPTRP00000073050 | Potassium voltage-gated channel interacting protein 1. | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | 0.740 |
| KCNIP3 | GUF1 | ENSPTRP00000020937 | ENSPTRP00000073050 | Potassium voltage-gated channel interacting protein 3. | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | 0.653 |
| MRPL19 | GUF1 | ENSPTRP00000020776 | ENSPTRP00000073050 | Mitochondrial ribosomal protein L19. | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | 0.652 |
| MRPL19 | MRPL20 | ENSPTRP00000020776 | ENSPTRP00000086537 | Mitochondrial ribosomal protein L19. | Mitochondrial ribosomal protein L20. | 0.984 |
| MRPL19 | MRPL27 | ENSPTRP00000020776 | ENSPTRP00000015958 | Mitochondrial ribosomal protein L19. | Mitochondrial ribosomal protein L27. | 0.981 |
| MRPL19 | MRPL32 | ENSPTRP00000020776 | ENSPTRP00000032659 | Mitochondrial ribosomal protein L19. | Mitochondrial ribosomal protein L32. | 0.984 |
| MRPL19 | MRPS6 | ENSPTRP00000020776 | ENSPTRP00000023883 | Mitochondrial ribosomal protein L19. | Mitochondrial ribosomal protein S6. | 0.967 |
| MRPL19 | MRPS9 | ENSPTRP00000020776 | ENSPTRP00000021085 | Mitochondrial ribosomal protein L19. | Mitochondrial ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. | 0.980 |
| MRPL20 | GUF1 | ENSPTRP00000086537 | ENSPTRP00000073050 | Mitochondrial ribosomal protein L20. | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. | 0.671 |
