| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1C3 | AKR1C4 | ENSPTRP00000078798 | ENSPTRP00000003803 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Aldo-keto reductase family 1 member C4. | 0.999 |
| AKR1C3 | CYP17A1 | ENSPTRP00000078798 | ENSPTRP00000069568 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.945 |
| AKR1C3 | CYP19A1 | ENSPTRP00000078798 | ENSPTRP00000012092 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.923 |
| AKR1C3 | HSD17B11 | ENSPTRP00000078798 | ENSPTRP00000044863 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxysteroid (17-beta) dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.913 |
| AKR1C3 | HSD17B2 | ENSPTRP00000078798 | ENSPTRP00000014332 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.947 |
| AKR1C3 | HSD17B3 | ENSPTRP00000078798 | ENSPTRP00000073561 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.947 |
| AKR1C3 | HSD17B8 | ENSPTRP00000078798 | ENSPTRP00000030804 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxysteroid (17-beta) dehydrogenase 8. | 0.914 |
| AKR1C3 | HSD3B1 | ENSPTRP00000078798 | ENSPTRP00000002008 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. | 0.923 |
| AKR1C3 | HSD3B2 | ENSPTRP00000078798 | ENSPTRP00000051923 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. | 0.940 |
| AKR1C3 | SRD5A1 | ENSPTRP00000078798 | ENSPTRP00000028677 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.935 |
| AKR1C4 | AKR1C3 | ENSPTRP00000003803 | ENSPTRP00000078798 | Aldo-keto reductase family 1 member C4. | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | 0.999 |
| AKR1C4 | CYP17A1 | ENSPTRP00000003803 | ENSPTRP00000069568 | Aldo-keto reductase family 1 member C4. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.918 |
| AKR1C4 | HSD17B11 | ENSPTRP00000003803 | ENSPTRP00000044863 | Aldo-keto reductase family 1 member C4. | Hydroxysteroid (17-beta) dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.910 |
| AKR1C4 | HSD17B3 | ENSPTRP00000003803 | ENSPTRP00000073561 | Aldo-keto reductase family 1 member C4. | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.928 |
| AKR1C4 | SRD5A1 | ENSPTRP00000003803 | ENSPTRP00000028677 | Aldo-keto reductase family 1 member C4. | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.921 |
| CYP17A1 | AKR1C3 | ENSPTRP00000069568 | ENSPTRP00000078798 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | 0.945 |
| CYP17A1 | AKR1C4 | ENSPTRP00000069568 | ENSPTRP00000003803 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Aldo-keto reductase family 1 member C4. | 0.918 |
| CYP17A1 | CYP19A1 | ENSPTRP00000069568 | ENSPTRP00000012092 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.957 |
| CYP17A1 | HSD17B11 | ENSPTRP00000069568 | ENSPTRP00000044863 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxysteroid (17-beta) dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.922 |
| CYP17A1 | HSD17B2 | ENSPTRP00000069568 | ENSPTRP00000014332 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.941 |
