| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAM2 | PRM1 | ENSPTRP00000063381 | ENSPTRP00000013259 | ADAM2 isoform 1. | Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | 0.561 |
| ADAM2 | SPAM1 | ENSPTRP00000063381 | ENSPTRP00000074848 | ADAM2 isoform 1. | Hyaluronidase. | 0.698 |
| ARSB | IDUA | ENSPTRP00000067780 | ENSPTRP00000027243 | Arylsulfatase B. | IDUA isoform 1. | 0.951 |
| ARSB | SPAM1 | ENSPTRP00000067780 | ENSPTRP00000074848 | Arylsulfatase B. | Hyaluronidase. | 0.911 |
| CCDC63 | SPAM1 | ENSPTRP00000009256 | ENSPTRP00000074848 | Coiled-coil domain containing 63. | Hyaluronidase. | 0.657 |
| CD44 | SPAM1 | ENSPTRP00000090745 | ENSPTRP00000074848 | CD44 isoform 3. | Hyaluronidase. | 0.725 |
| DPM2 | SPAM1 | ENSPTRP00000036589 | ENSPTRP00000074848 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. | Hyaluronidase. | 0.668 |
| GUSB-2 | SPAM1 | ENSPTRP00000089661 | ENSPTRP00000074848 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | Hyaluronidase. | 0.915 |
| IDUA | ARSB | ENSPTRP00000027243 | ENSPTRP00000067780 | IDUA isoform 1. | Arylsulfatase B. | 0.951 |
| IDUA | SPAM1 | ENSPTRP00000027243 | ENSPTRP00000074848 | IDUA isoform 1. | Hyaluronidase. | 0.920 |
| PRM1 | ADAM2 | ENSPTRP00000013259 | ENSPTRP00000063381 | Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | ADAM2 isoform 1. | 0.561 |
| PRM1 | SPAM1 | ENSPTRP00000013259 | ENSPTRP00000074848 | Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | Hyaluronidase. | 0.787 |
| SPAG9 | SPAM1 | ENSPTRP00000066446 | ENSPTRP00000074848 | Sperm associated antigen 9. | Hyaluronidase. | 0.727 |
| SPAM1 | ADAM2 | ENSPTRP00000074848 | ENSPTRP00000063381 | Hyaluronidase. | ADAM2 isoform 1. | 0.698 |
| SPAM1 | ARSB | ENSPTRP00000074848 | ENSPTRP00000067780 | Hyaluronidase. | Arylsulfatase B. | 0.911 |
| SPAM1 | CCDC63 | ENSPTRP00000074848 | ENSPTRP00000009256 | Hyaluronidase. | Coiled-coil domain containing 63. | 0.657 |
| SPAM1 | CD44 | ENSPTRP00000074848 | ENSPTRP00000090745 | Hyaluronidase. | CD44 isoform 3. | 0.725 |
| SPAM1 | DPM2 | ENSPTRP00000074848 | ENSPTRP00000036589 | Hyaluronidase. | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. | 0.668 |
| SPAM1 | GUSB-2 | ENSPTRP00000074848 | ENSPTRP00000089661 | Hyaluronidase. | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | 0.915 |
| SPAM1 | IDUA | ENSPTRP00000074848 | ENSPTRP00000027243 | Hyaluronidase. | IDUA isoform 1. | 0.920 |
