LDLR protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOB	APOE	ENSPTRP00000052150	ENSPTRP00000054411	APOB isoform 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.998
APOB	DAB2	ENSPTRP00000052150	ENSPTRP00000071697	APOB isoform 1.	Disabled homolog 2, mitogen-responsive phosphoprotein.	0.733
APOB	LDLR	ENSPTRP00000052150	ENSPTRP00000075226	APOB isoform 1.	LDLR isoform 7.	0.998
APOB	LDLRAP1	ENSPTRP00000052150	ENSPTRP00000000643	APOB isoform 1.	Low density lipoprotein receptor adaptor protein 1.	0.925
APOB	PCSK9	ENSPTRP00000052150	ENSPTRP00000001355	APOB isoform 1.	Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...]	0.815
APOB	SREBF2	ENSPTRP00000052150	ENSPTRP00000024869	APOB isoform 1.	Sterol regulatory element binding transcription factor 2.	0.429
APOE	APOB	ENSPTRP00000054411	ENSPTRP00000052150	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	APOB isoform 1.	0.998
APOE	LDLR	ENSPTRP00000054411	ENSPTRP00000075226	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	LDLR isoform 7.	0.975
APOE	LDLRAP1	ENSPTRP00000054411	ENSPTRP00000000643	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Low density lipoprotein receptor adaptor protein 1.	0.544
APOE	PCSK9	ENSPTRP00000054411	ENSPTRP00000001355	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...]	0.583
APOE	RELN	ENSPTRP00000054411	ENSPTRP00000056975	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	RELN isoform 3.	0.427
APOE	SREBF2	ENSPTRP00000054411	ENSPTRP00000024869	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Sterol regulatory element binding transcription factor 2.	0.429
DAB1	LDLR	ENSPTRP00000052263	ENSPTRP00000075226	DAB adaptor protein 1.	LDLR isoform 7.	0.876
DAB1	RELN	ENSPTRP00000052263	ENSPTRP00000056975	DAB adaptor protein 1.	RELN isoform 3.	0.953
DAB2	APOB	ENSPTRP00000071697	ENSPTRP00000052150	Disabled homolog 2, mitogen-responsive phosphoprotein.	APOB isoform 1.	0.733
DAB2	LDLR	ENSPTRP00000071697	ENSPTRP00000075226	Disabled homolog 2, mitogen-responsive phosphoprotein.	LDLR isoform 7.	0.960
DAB2	LDLRAP1	ENSPTRP00000071697	ENSPTRP00000000643	Disabled homolog 2, mitogen-responsive phosphoprotein.	Low density lipoprotein receptor adaptor protein 1.	0.919
DAB2	RELN	ENSPTRP00000071697	ENSPTRP00000056975	Disabled homolog 2, mitogen-responsive phosphoprotein.	RELN isoform 3.	0.497
HMGCS1	LDLR	ENSPTRP00000028865	ENSPTRP00000075226	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	LDLR isoform 7.	0.906
HMGCS1	SREBF2	ENSPTRP00000028865	ENSPTRP00000024869	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Sterol regulatory element binding transcription factor 2.	0.720