| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SMAD2 | SMAD3 | ENSPTRP00000062376 | ENSPTRP00000090625 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.999 |
| SMAD2 | SMAD4 | ENSPTRP00000062376 | ENSPTRP00000017047 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.999 |
| SMAD2 | SMAD7 | ENSPTRP00000062376 | ENSPTRP00000017016 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.991 |
| SMAD2 | SMURF1 | ENSPTRP00000062376 | ENSPTRP00000047812 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.920 |
| SMAD2 | SMURF2 | ENSPTRP00000062376 | ENSPTRP00000088535 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.993 |
| SMAD2 | TGFB1 | ENSPTRP00000062376 | ENSPTRP00000018930 | Mothers against decapentaplegic homolog. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.913 |
| SMAD2 | TGFB2 | ENSPTRP00000062376 | ENSPTRP00000003339 | Mothers against decapentaplegic homolog. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.794 |
| SMAD2 | TGFB3 | ENSPTRP00000062376 | ENSPTRP00000011150 | Mothers against decapentaplegic homolog. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.765 |
| SMAD2 | TGFBR1 | ENSPTRP00000062376 | ENSPTRP00000073078 | Mothers against decapentaplegic homolog. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.998 |
| SMAD2 | TGFBR2 | ENSPTRP00000062376 | ENSPTRP00000075305 | Mothers against decapentaplegic homolog. | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.990 |
| SMAD3 | SMAD2 | ENSPTRP00000090625 | ENSPTRP00000062376 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.999 |
| SMAD3 | SMAD4 | ENSPTRP00000090625 | ENSPTRP00000017047 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.999 |
| SMAD3 | SMAD7 | ENSPTRP00000090625 | ENSPTRP00000017016 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.990 |
| SMAD3 | SMURF1 | ENSPTRP00000090625 | ENSPTRP00000047812 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.951 |
| SMAD3 | SMURF2 | ENSPTRP00000090625 | ENSPTRP00000088535 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.984 |
| SMAD3 | TGFB1 | ENSPTRP00000090625 | ENSPTRP00000018930 | Mothers against decapentaplegic homolog. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.922 |
| SMAD3 | TGFB2 | ENSPTRP00000090625 | ENSPTRP00000003339 | Mothers against decapentaplegic homolog. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.828 |
| SMAD3 | TGFB3 | ENSPTRP00000090625 | ENSPTRP00000011150 | Mothers against decapentaplegic homolog. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.762 |
| SMAD3 | TGFBR1 | ENSPTRP00000090625 | ENSPTRP00000073078 | Mothers against decapentaplegic homolog. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.997 |
| SMAD3 | TGFBR2 | ENSPTRP00000090625 | ENSPTRP00000075305 | Mothers against decapentaplegic homolog. | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.989 |
