BARD1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABRAXAS1	BABAM1	ENSPTRP00000053580	ENSPTRP00000018199	Family with sequence similarity 175, member A.	Chromosome 19 open reading frame 62.	0.998
ABRAXAS1	BARD1	ENSPTRP00000053580	ENSPTRP00000075471	Family with sequence similarity 175, member A.	BRCA1 associated RING domain 1.	0.983
ABRAXAS1	BRCA1	ENSPTRP00000053580	ENSPTRP00000070120	Family with sequence similarity 175, member A.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.997
ABRAXAS1	BRCC3	ENSPTRP00000053580	ENSPTRP00000072574	Family with sequence similarity 175, member A.	BRCA1/BRCA2-containing complex subunit 3.	0.969
ABRAXAS1	ENSPTRP00000083584	ENSPTRP00000053580	ENSPTRP00000083584	Family with sequence similarity 175, member A.	annotation not available	0.969
ABRAXAS1	RBBP8	ENSPTRP00000053580	ENSPTRP00000039280	Family with sequence similarity 175, member A.	RB binding protein 8, endonuclease.	0.663
ABRAXAS1	UIMC1	ENSPTRP00000053580	ENSPTRP00000078622	Family with sequence similarity 175, member A.	Ubiquitin interaction motif containing 1.	0.994
BABAM1	ABRAXAS1	ENSPTRP00000018199	ENSPTRP00000053580	Chromosome 19 open reading frame 62.	Family with sequence similarity 175, member A.	0.998
BABAM1	BARD1	ENSPTRP00000018199	ENSPTRP00000075471	Chromosome 19 open reading frame 62.	BRCA1 associated RING domain 1.	0.992
BABAM1	BRCA1	ENSPTRP00000018199	ENSPTRP00000070120	Chromosome 19 open reading frame 62.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.997
BABAM1	BRCC3	ENSPTRP00000018199	ENSPTRP00000072574	Chromosome 19 open reading frame 62.	BRCA1/BRCA2-containing complex subunit 3.	0.996
BABAM1	ENSPTRP00000083584	ENSPTRP00000018199	ENSPTRP00000083584	Chromosome 19 open reading frame 62.	annotation not available	0.996
BABAM1	RBBP8	ENSPTRP00000018199	ENSPTRP00000039280	Chromosome 19 open reading frame 62.	RB binding protein 8, endonuclease.	0.545
BABAM1	UIMC1	ENSPTRP00000018199	ENSPTRP00000078622	Chromosome 19 open reading frame 62.	Ubiquitin interaction motif containing 1.	0.999
BARD1	ABRAXAS1	ENSPTRP00000075471	ENSPTRP00000053580	BRCA1 associated RING domain 1.	Family with sequence similarity 175, member A.	0.983
BARD1	BABAM1	ENSPTRP00000075471	ENSPTRP00000018199	BRCA1 associated RING domain 1.	Chromosome 19 open reading frame 62.	0.992
BARD1	BRCA1	ENSPTRP00000075471	ENSPTRP00000070120	BRCA1 associated RING domain 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BARD1	BRCA2	ENSPTRP00000075471	ENSPTRP00000009812	BRCA1 associated RING domain 1.	Breast cancer 2, early onset.	0.984
BARD1	BRCC3	ENSPTRP00000075471	ENSPTRP00000072574	BRCA1 associated RING domain 1.	BRCA1/BRCA2-containing complex subunit 3.	0.989
BARD1	BRIP1	ENSPTRP00000075471	ENSPTRP00000016108	BRCA1 associated RING domain 1.	BRCA1 interacting protein C-terminal helicase 1.	0.983