| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRCA1 | CDKN2B | ENSPTRP00000070120 | ENSPTRP00000082876 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). | 0.489 |
| BRCA1 | EP300 | ENSPTRP00000070120 | ENSPTRP00000024841 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | E1A binding protein p300. | 0.931 |
| BRCA1 | MYC | ENSPTRP00000070120 | ENSPTRP00000075568 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.962 |
| CDKN2B | BRCA1 | ENSPTRP00000082876 | ENSPTRP00000070120 | Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.489 |
| CDKN2B | EP300 | ENSPTRP00000082876 | ENSPTRP00000024841 | Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). | E1A binding protein p300. | 0.421 |
| CDKN2B | MYC | ENSPTRP00000082876 | ENSPTRP00000075568 | Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.987 |
| EP300 | BRCA1 | ENSPTRP00000024841 | ENSPTRP00000070120 | E1A binding protein p300. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.931 |
| EP300 | CDKN2B | ENSPTRP00000024841 | ENSPTRP00000082876 | E1A binding protein p300. | Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). | 0.421 |
| EP300 | MAPK1 | ENSPTRP00000024841 | ENSPTRP00000024313 | E1A binding protein p300. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.779 |
| EP300 | MAPK3 | ENSPTRP00000024841 | ENSPTRP00000053615 | E1A binding protein p300. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.610 |
| EP300 | MAX | ENSPTRP00000024841 | ENSPTRP00000087706 | E1A binding protein p300. | MYC associated factor X. | 0.742 |
| EP300 | MYC | ENSPTRP00000024841 | ENSPTRP00000075568 | E1A binding protein p300. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.959 |
| EP300 | ZBTB17 | ENSPTRP00000024841 | ENSPTRP00000000387 | E1A binding protein p300. | Zinc finger and BTB domain containing 17. | 0.627 |
| FBXW7 | GSK3B | ENSPTRP00000028353 | ENSPTRP00000081705 | F-box and WD repeat domain containing 7. | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | 0.526 |
| FBXW7 | MAPK1 | ENSPTRP00000028353 | ENSPTRP00000024313 | F-box and WD repeat domain containing 7. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.511 |
| FBXW7 | MAPK3 | ENSPTRP00000028353 | ENSPTRP00000053615 | F-box and WD repeat domain containing 7. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.675 |
| FBXW7 | MAX | ENSPTRP00000028353 | ENSPTRP00000087706 | F-box and WD repeat domain containing 7. | MYC associated factor X. | 0.534 |
| FBXW7 | MYC | ENSPTRP00000028353 | ENSPTRP00000075568 | F-box and WD repeat domain containing 7. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.961 |
| FBXW7 | USP28 | ENSPTRP00000028353 | ENSPTRP00000088705 | F-box and WD repeat domain containing 7. | USP28 isoform 2; Belongs to the peptidase C19 family. | 0.508 |
| GSK3B | FBXW7 | ENSPTRP00000081705 | ENSPTRP00000028353 | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | F-box and WD repeat domain containing 7. | 0.526 |
