RTEL1-4 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	BLM	ENSPTRP00000075471	ENSPTRP00000012754	BRCA1 associated RING domain 1.	BLM isoform 1.	0.860
BARD1	BRCA1	ENSPTRP00000075471	ENSPTRP00000070120	BRCA1 associated RING domain 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BARD1	MLH1	ENSPTRP00000075471	ENSPTRP00000025426	BRCA1 associated RING domain 1.	MutL homolog 1, colon cancer, nonpolyposis type 2.	0.701
BARD1	NBN	ENSPTRP00000075471	ENSPTRP00000053119	BRCA1 associated RING domain 1.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.981
BARD1	RTEL1-4	ENSPTRP00000075471	ENSPTRP00000076045	BRCA1 associated RING domain 1.	Regulator of telomere elongation helicase 1.	0.823
BARD1	SLF1	ENSPTRP00000075471	ENSPTRP00000029231	BRCA1 associated RING domain 1.	SLF1 isoform 2.	0.891
BARD1	SLX4	ENSPTRP00000075471	ENSPTRP00000013163	BRCA1 associated RING domain 1.	SLX4 structure-specific endonuclease subunit.	0.722
BARD1	TOPBP1	ENSPTRP00000075471	ENSPTRP00000026557	BRCA1 associated RING domain 1.	Topoisomerase (DNA) II binding protein 1.	0.990
BARD1	WRN	ENSPTRP00000075471	ENSPTRP00000091996	BRCA1 associated RING domain 1.	WRN RecQ like helicase.	0.956
BLM	BARD1	ENSPTRP00000012754	ENSPTRP00000075471	BLM isoform 1.	BRCA1 associated RING domain 1.	0.860
BLM	BRCA1	ENSPTRP00000012754	ENSPTRP00000070120	BLM isoform 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.947
BLM	MLH1	ENSPTRP00000012754	ENSPTRP00000025426	BLM isoform 1.	MutL homolog 1, colon cancer, nonpolyposis type 2.	0.964
BLM	NBN	ENSPTRP00000012754	ENSPTRP00000053119	BLM isoform 1.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.936
BLM	RTEL1-4	ENSPTRP00000012754	ENSPTRP00000076045	BLM isoform 1.	Regulator of telomere elongation helicase 1.	0.735
BLM	SLF1	ENSPTRP00000012754	ENSPTRP00000029231	BLM isoform 1.	SLF1 isoform 2.	0.774
BLM	SLX4	ENSPTRP00000012754	ENSPTRP00000013163	BLM isoform 1.	SLX4 structure-specific endonuclease subunit.	0.670
BLM	TOPBP1	ENSPTRP00000012754	ENSPTRP00000026557	BLM isoform 1.	Topoisomerase (DNA) II binding protein 1.	0.916
BLM	WRN	ENSPTRP00000012754	ENSPTRP00000091996	BLM isoform 1.	WRN RecQ like helicase.	0.608
BRCA1	BARD1	ENSPTRP00000070120	ENSPTRP00000075471	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 associated RING domain 1.	0.999
BRCA1	BLM	ENSPTRP00000070120	ENSPTRP00000012754	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BLM isoform 1.	0.947