C2 protein (Pan troglodytes) - STRING interaction network

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C2

Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity). (1112 aa)

Predicted Functional Partners:

C3

0.996

CFH

0.960

CFP

0.915

CFD

0.886

CFI

0.826

LOC462577

0.761

LOC100616513

0.761

LOC462577-2

0.761

C5

0.760

SERPING1

0.735

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C2	C3	ENSPTRP00000076687	ENSPTRP00000017648	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Complement component 3.	0.996
C2	C5	ENSPTRP00000076687	ENSPTRP00000036418	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Complement C5.	0.760
C2	CFD	ENSPTRP00000076687	ENSPTRP00000049176	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Complement factor D.	0.886
C2	CFH	ENSPTRP00000076687	ENSPTRP00000003002	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	CFH isoform 2.	0.960
C2	CFI	ENSPTRP00000076687	ENSPTRP00000053358	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Complement factor I; Belongs to the peptidase S1 family.	0.826
C2	CFP	ENSPTRP00000076687	ENSPTRP00000037513	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Complement factor properdin.	0.915
C2	LOC100616513	ENSPTRP00000076687	ENSPTRP00000064762	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Complement C4-A-like.	0.761
C2	LOC462577	ENSPTRP00000076687	ENSPTRP00000064661	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	C4B isoform 1.	0.761
C2	LOC462577-2	ENSPTRP00000076687	ENSPTRP00000067300	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Complement C4-A.	0.761
C2	SERPING1	ENSPTRP00000076687	ENSPTRP00000088468	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family.	0.735
C3	C2	ENSPTRP00000017648	ENSPTRP00000076687	Complement component 3.	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	0.996
C3	C5	ENSPTRP00000017648	ENSPTRP00000036418	Complement component 3.	Complement C5.	0.979
C3	CFD	ENSPTRP00000017648	ENSPTRP00000049176	Complement component 3.	Complement factor D.	0.937
C3	CFH	ENSPTRP00000017648	ENSPTRP00000003002	Complement component 3.	CFH isoform 2.	0.918
C3	CFI	ENSPTRP00000017648	ENSPTRP00000053358	Complement component 3.	Complement factor I; Belongs to the peptidase S1 family.	0.998
C3	CFP	ENSPTRP00000017648	ENSPTRP00000037513	Complement component 3.	Complement factor properdin.	0.999
C3	LOC100616513	ENSPTRP00000017648	ENSPTRP00000064762	Complement component 3.	Complement C4-A-like.	0.590
C3	LOC462577	ENSPTRP00000017648	ENSPTRP00000064661	Complement component 3.	C4B isoform 1.	0.957
C3	LOC462577-2	ENSPTRP00000017648	ENSPTRP00000067300	Complement component 3.	Complement C4-A.	0.590
C3	SERPING1	ENSPTRP00000017648	ENSPTRP00000088468	Complement component 3.	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family.	0.755

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