UIMC1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABRAXAS1	BABAM1	ENSPTRP00000053580	ENSPTRP00000018199	Family with sequence similarity 175, member A.	Chromosome 19 open reading frame 62.	0.998
ABRAXAS1	BABAM2	ENSPTRP00000053580	ENSPTRP00000090234	Family with sequence similarity 175, member A.	BRISC and BRCA1-A complex member 2 isoform X2.	0.990
ABRAXAS1	BARD1	ENSPTRP00000053580	ENSPTRP00000075471	Family with sequence similarity 175, member A.	BRCA1 associated RING domain 1.	0.983
ABRAXAS1	BRCA1	ENSPTRP00000053580	ENSPTRP00000070120	Family with sequence similarity 175, member A.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.997
ABRAXAS1	BRCC3	ENSPTRP00000053580	ENSPTRP00000072574	Family with sequence similarity 175, member A.	BRCA1/BRCA2-containing complex subunit 3.	0.969
ABRAXAS1	ENSPTRP00000083584	ENSPTRP00000053580	ENSPTRP00000083584	Family with sequence similarity 175, member A.	annotation not available	0.969
ABRAXAS1	MDC1	ENSPTRP00000053580	ENSPTRP00000042596	Family with sequence similarity 175, member A.	Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be ac [...]	0.855
ABRAXAS1	UBC	ENSPTRP00000053580	ENSPTRP00000050925	Family with sequence similarity 175, member A.	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.766
ABRAXAS1	UIMC1	ENSPTRP00000053580	ENSPTRP00000078622	Family with sequence similarity 175, member A.	Ubiquitin interaction motif containing 1.	0.994
BABAM1	ABRAXAS1	ENSPTRP00000018199	ENSPTRP00000053580	Chromosome 19 open reading frame 62.	Family with sequence similarity 175, member A.	0.998
BABAM1	BABAM2	ENSPTRP00000018199	ENSPTRP00000090234	Chromosome 19 open reading frame 62.	BRISC and BRCA1-A complex member 2 isoform X2.	0.999
BABAM1	BARD1	ENSPTRP00000018199	ENSPTRP00000075471	Chromosome 19 open reading frame 62.	BRCA1 associated RING domain 1.	0.992
BABAM1	BRCA1	ENSPTRP00000018199	ENSPTRP00000070120	Chromosome 19 open reading frame 62.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.997
BABAM1	BRCC3	ENSPTRP00000018199	ENSPTRP00000072574	Chromosome 19 open reading frame 62.	BRCA1/BRCA2-containing complex subunit 3.	0.996
BABAM1	CK820_G0003646	ENSPTRP00000018199	ENSPTRP00000061481	Chromosome 19 open reading frame 62.	ABRAXAS1 isoform 9.	0.970
BABAM1	ENSPTRP00000083584	ENSPTRP00000018199	ENSPTRP00000083584	Chromosome 19 open reading frame 62.	annotation not available	0.996
BABAM1	MDC1	ENSPTRP00000018199	ENSPTRP00000042596	Chromosome 19 open reading frame 62.	Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be ac [...]	0.768
BABAM1	UBC	ENSPTRP00000018199	ENSPTRP00000050925	Chromosome 19 open reading frame 62.	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.431
BABAM1	UIMC1	ENSPTRP00000018199	ENSPTRP00000078622	Chromosome 19 open reading frame 62.	Ubiquitin interaction motif containing 1.	0.999
BABAM2	ABRAXAS1	ENSPTRP00000090234	ENSPTRP00000053580	BRISC and BRCA1-A complex member 2 isoform X2.	Family with sequence similarity 175, member A.	0.990