| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DNA2 | EME1 | ENSPTRP00000063857 | ENSPTRP00000015960 | DNA2 isoform 3. | Essential meiotic structure-specific endonuclease 1. | 0.841 |
| DNA2 | EXO1 | ENSPTRP00000063857 | ENSPTRP00000003664 | DNA2 isoform 3. | EXO1 isoform 1. | 0.982 |
| DNA2 | GEN1 | ENSPTRP00000063857 | ENSPTRP00000081984 | DNA2 isoform 3. | GEN1 Holliday junction 5' flap endonuclease. | 0.870 |
| DNA2 | MUS81 | ENSPTRP00000063857 | ENSPTRP00000006717 | DNA2 isoform 3. | MUS81 structure-specific endonuclease subunit. | 0.903 |
| DNA2 | RMI2 | ENSPTRP00000063857 | ENSPTRP00000013261 | DNA2 isoform 3. | Chromosome 16 open reading frame 75. | 0.815 |
| DNA2 | SLX1A | ENSPTRP00000063857 | ENSPTRP00000058845 | DNA2 isoform 3. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.793 |
| DNA2 | SLX4 | ENSPTRP00000063857 | ENSPTRP00000013163 | DNA2 isoform 3. | SLX4 structure-specific endonuclease subunit. | 0.734 |
| DNA2 | WRN | ENSPTRP00000063857 | ENSPTRP00000091996 | DNA2 isoform 3. | WRN RecQ like helicase. | 0.991 |
| EME1 | DNA2 | ENSPTRP00000015960 | ENSPTRP00000063857 | Essential meiotic structure-specific endonuclease 1. | DNA2 isoform 3. | 0.841 |
| EME1 | EXO1 | ENSPTRP00000015960 | ENSPTRP00000003664 | Essential meiotic structure-specific endonuclease 1. | EXO1 isoform 1. | 0.880 |
| EME1 | GEN1 | ENSPTRP00000015960 | ENSPTRP00000081984 | Essential meiotic structure-specific endonuclease 1. | GEN1 Holliday junction 5' flap endonuclease. | 0.771 |
| EME1 | MUS81 | ENSPTRP00000015960 | ENSPTRP00000006717 | Essential meiotic structure-specific endonuclease 1. | MUS81 structure-specific endonuclease subunit. | 0.999 |
| EME1 | RMI2 | ENSPTRP00000015960 | ENSPTRP00000013261 | Essential meiotic structure-specific endonuclease 1. | Chromosome 16 open reading frame 75. | 0.894 |
| EME1 | SLX1A | ENSPTRP00000015960 | ENSPTRP00000058845 | Essential meiotic structure-specific endonuclease 1. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.965 |
| EME1 | SLX4 | ENSPTRP00000015960 | ENSPTRP00000013163 | Essential meiotic structure-specific endonuclease 1. | SLX4 structure-specific endonuclease subunit. | 0.993 |
| EME1 | WRN | ENSPTRP00000015960 | ENSPTRP00000091996 | Essential meiotic structure-specific endonuclease 1. | WRN RecQ like helicase. | 0.788 |
| EXO1 | DNA2 | ENSPTRP00000003664 | ENSPTRP00000063857 | EXO1 isoform 1. | DNA2 isoform 3. | 0.982 |
| EXO1 | EME1 | ENSPTRP00000003664 | ENSPTRP00000015960 | EXO1 isoform 1. | Essential meiotic structure-specific endonuclease 1. | 0.880 |
| EXO1 | GEN1 | ENSPTRP00000003664 | ENSPTRP00000081984 | EXO1 isoform 1. | GEN1 Holliday junction 5' flap endonuclease. | 0.731 |
| EXO1 | MUS81 | ENSPTRP00000003664 | ENSPTRP00000006717 | EXO1 isoform 1. | MUS81 structure-specific endonuclease subunit. | 0.924 |
