MET protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	GRB2	ENSPTRP00000007497	ENSPTRP00000016382	Cas-Br-M (Murine) ecotropic retroviral transforming sequence.	Growth factor receptor-bound protein 2.	0.997
CBL	HGF	ENSPTRP00000007497	ENSPTRP00000072810	Cas-Br-M (Murine) ecotropic retroviral transforming sequence.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.692
CBL	MET	ENSPTRP00000007497	ENSPTRP00000083162	Cas-Br-M (Murine) ecotropic retroviral transforming sequence.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.995
CBL	PIK3CA	ENSPTRP00000007497	ENSPTRP00000084763	Cas-Br-M (Murine) ecotropic retroviral transforming sequence.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.971
CBL	SRC	ENSPTRP00000007497	ENSPTRP00000076797	Cas-Br-M (Murine) ecotropic retroviral transforming sequence.	Tyrosine-protein kinase.	0.975
GAB1	GRB2	ENSPTRP00000028277	ENSPTRP00000016382	GRB2-associated-binding protein 1.	Growth factor receptor-bound protein 2.	0.999
GAB1	HGF	ENSPTRP00000028277	ENSPTRP00000072810	GRB2-associated-binding protein 1.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.883
GAB1	MET	ENSPTRP00000028277	ENSPTRP00000083162	GRB2-associated-binding protein 1.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.992
GAB1	PIK3CA	ENSPTRP00000028277	ENSPTRP00000084763	GRB2-associated-binding protein 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.980
GAB1	SRC	ENSPTRP00000028277	ENSPTRP00000076797	GRB2-associated-binding protein 1.	Tyrosine-protein kinase.	0.697
GRB2	CBL	ENSPTRP00000016382	ENSPTRP00000007497	Growth factor receptor-bound protein 2.	Cas-Br-M (Murine) ecotropic retroviral transforming sequence.	0.997
GRB2	GAB1	ENSPTRP00000016382	ENSPTRP00000028277	Growth factor receptor-bound protein 2.	GRB2-associated-binding protein 1.	0.999
GRB2	HGF	ENSPTRP00000016382	ENSPTRP00000072810	Growth factor receptor-bound protein 2.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.666
GRB2	MET	ENSPTRP00000016382	ENSPTRP00000083162	Growth factor receptor-bound protein 2.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.996
GRB2	PIK3CA	ENSPTRP00000016382	ENSPTRP00000084763	Growth factor receptor-bound protein 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.958
GRB2	PLXNB1	ENSPTRP00000016382	ENSPTRP00000025675	Growth factor receptor-bound protein 2.	PLXNB1 isoform 1.	0.618
GRB2	PLXNB3	ENSPTRP00000016382	ENSPTRP00000092121	Growth factor receptor-bound protein 2.	PLXNB3 isoform 1.	0.422
GRB2	PTPN1	ENSPTRP00000016382	ENSPTRP00000043532	Growth factor receptor-bound protein 2.	Tyrosine-protein phosphatase non-receptor type.	0.810
GRB2	SRC	ENSPTRP00000016382	ENSPTRP00000076797	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase.	0.984
HGF	CBL	ENSPTRP00000072810	ENSPTRP00000007497	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Cas-Br-M (Murine) ecotropic retroviral transforming sequence.	0.692