STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CFL1CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. (204 aa)    
Predicted Functional Partners:
LIMK1-2
LIM domain kinase 1.
   
 0.998
ACTB
Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
   
 0.993
LIMK2
LIMK2 isoform 6.
   
 0.991
SSH1
Slingshot homolog 1.
    
 0.982
LIMK1
LIM domain kinase 1.
   
 0.981
SSH2
Slingshot protein phosphatase 2.
    
 0.976
SSH3
Slingshot protein phosphatase 3.
    
 0.971
CFL2
Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family.
  
 
0.969
ENSPTRP00000064849
annotation not available
   
 
 0.937
ACTA1
Actin alpha 1, skeletal muscle.
   
 
 0.916
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.