CERK protein (Pan troglodytes) - STRING interaction network

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CERK

Ceramide kinase. (539 aa)

Predicted Functional Partners:

ASAH2

0.963

PLPP1

0.961

ACER1

0.960

ASAH1

0.958

UGCG

0.953

GBA2

0.945

CERS2

0.944

SGPP2

0.944

SGMS1

0.942

SMPD1

0.940

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACER1	ASAH1	ENSPTRP00000017621	ENSPTRP00000063559	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	0.963
ACER1	ASAH2	ENSPTRP00000017621	ENSPTRP00000090739	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Neutral ceramidase.	0.954
ACER1	CERK	ENSPTRP00000017621	ENSPTRP00000087585	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Ceramide kinase.	0.960
ACER1	CERS2	ENSPTRP00000017621	ENSPTRP00000040517	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	LAG1 homolog, ceramide synthase 2.	0.937
ACER1	GBA2	ENSPTRP00000017621	ENSPTRP00000035782	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.	0.921
ACER1	PLPP1	ENSPTRP00000017621	ENSPTRP00000028918	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Phospholipid phosphatase 1.	0.906
ACER1	SGMS1	ENSPTRP00000017621	ENSPTRP00000004317	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Sphingomyelin synthase 1.	0.923
ACER1	SGPP2	ENSPTRP00000017621	ENSPTRP00000078528	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Sphingosine-1-phosphate phosphatase 2.	0.915
ACER1	SMPD1	ENSPTRP00000017621	ENSPTRP00000005756	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.923
ACER1	UGCG	ENSPTRP00000017621	ENSPTRP00000065363	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	UDP-glucose ceramide glucosyltransferase.	0.926
ASAH1	ACER1	ENSPTRP00000063559	ENSPTRP00000017621	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.963
ASAH1	ASAH2	ENSPTRP00000063559	ENSPTRP00000090739	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Neutral ceramidase.	0.956
ASAH1	CERK	ENSPTRP00000063559	ENSPTRP00000087585	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Ceramide kinase.	0.958
ASAH1	CERS2	ENSPTRP00000063559	ENSPTRP00000040517	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	LAG1 homolog, ceramide synthase 2.	0.947
ASAH1	GBA2	ENSPTRP00000063559	ENSPTRP00000035782	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.	0.957
ASAH1	PLPP1	ENSPTRP00000063559	ENSPTRP00000028918	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Phospholipid phosphatase 1.	0.925
ASAH1	SGMS1	ENSPTRP00000063559	ENSPTRP00000004317	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingomyelin synthase 1.	0.940
ASAH1	SGPP2	ENSPTRP00000063559	ENSPTRP00000078528	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingosine-1-phosphate phosphatase 2.	0.931
ASAH1	SMPD1	ENSPTRP00000063559	ENSPTRP00000005756	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.963
ASAH1	UGCG	ENSPTRP00000063559	ENSPTRP00000065363	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	UDP-glucose ceramide glucosyltransferase.	0.947