PIK3C3 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG13	ATG14	ENSPTRP00000079168	ENSPTRP00000010813	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	ATG14 autophagy related 14 homolog.	0.992
ATG13	BECN1-2	ENSPTRP00000079168	ENSPTRP00000093335	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	BECN1 isoform 3.	0.991
ATG13	BECN2	ENSPTRP00000079168	ENSPTRP00000068224	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	BECN2 isoform 1.	0.983
ATG13	NRBF2	ENSPTRP00000079168	ENSPTRP00000055273	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	Nuclear receptor binding factor 2.	0.947
ATG13	PIK3C3	ENSPTRP00000079168	ENSPTRP00000091735	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.989
ATG13	PIK3R4	ENSPTRP00000079168	ENSPTRP00000026520	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	Phosphoinositide-3-kinase, regulatory subunit 4.	0.983
ATG13	RB1CC1	ENSPTRP00000079168	ENSPTRP00000034671	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	RB1-inducible coiled-coil 1.	0.999
ATG13	ULK2	ENSPTRP00000079168	ENSPTRP00000092410	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.997
ATG13	UVRAG	ENSPTRP00000079168	ENSPTRP00000007026	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	UV radiation resistance associated protein.	0.685
ATG14	ATG13	ENSPTRP00000010813	ENSPTRP00000079168	ATG14 autophagy related 14 homolog.	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	0.992
ATG14	BECN1-2	ENSPTRP00000010813	ENSPTRP00000093335	ATG14 autophagy related 14 homolog.	BECN1 isoform 3.	0.998
ATG14	BECN2	ENSPTRP00000010813	ENSPTRP00000068224	ATG14 autophagy related 14 homolog.	BECN2 isoform 1.	0.994
ATG14	NRBF2	ENSPTRP00000010813	ENSPTRP00000055273	ATG14 autophagy related 14 homolog.	Nuclear receptor binding factor 2.	0.995
ATG14	PIK3C3	ENSPTRP00000010813	ENSPTRP00000091735	ATG14 autophagy related 14 homolog.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.999
ATG14	PIK3R4	ENSPTRP00000010813	ENSPTRP00000026520	ATG14 autophagy related 14 homolog.	Phosphoinositide-3-kinase, regulatory subunit 4.	0.999
ATG14	RB1CC1	ENSPTRP00000010813	ENSPTRP00000034671	ATG14 autophagy related 14 homolog.	RB1-inducible coiled-coil 1.	0.998
ATG14	ULK2	ENSPTRP00000010813	ENSPTRP00000092410	ATG14 autophagy related 14 homolog.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.994
ATG14	UVRAG	ENSPTRP00000010813	ENSPTRP00000007026	ATG14 autophagy related 14 homolog.	UV radiation resistance associated protein.	0.933
BECN1-2	ATG13	ENSPTRP00000093335	ENSPTRP00000079168	BECN1 isoform 3.	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	0.991
BECN1-2	ATG14	ENSPTRP00000093335	ENSPTRP00000010813	BECN1 isoform 3.	ATG14 autophagy related 14 homolog.	0.998