Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPP1Secreted phosphoprotein 1. (314 aa)    
Predicted Functional Partners:
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
    
 0.985
ITGA9
Integrin subunit alpha 9; Belongs to the integrin alpha chain family.
   
 0.978
CD44
CD44 isoform 3.
   
 0.977
ITGAV
Integrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family.
   
 0.976
ITGB3
Integrin beta-3 isoform X2.
    
 0.974
ITGA4
Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor); Belongs to the integrin alpha chain family.
   
 0.960
ITGB5
Integrin beta; Belongs to the integrin beta chain family.
    
 0.957
MMP7
Matrix metallopeptidase 7.
   
 0.936
IRF7
Interferon regulatory factor 7.
    
 0.920
ITGA5
ITGA5 isoform 2; Belongs to the integrin alpha chain family.
   
 0.895
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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