STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRR2ASmall proline-rich protein 2A. (72 aa)    
Predicted Functional Partners:
SPRR3
Small proline rich protein 3.
   
 
 0.726
ELF3
E74 like ETS transcription factor 3.
      
 0.650
POU2F3
POU domain protein.
      
 0.638
IVL
Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
   
 
 0.611
LCE3D
Late cornified envelope 3D.
   
 
 0.513
PI3
Peptidase inhibitor 3, skin-derived.
     
 0.504
LCE3E
Late cornified envelope 3E.
   
 
 0.473
RPTN
RPTN isoform 1.
   
 
 0.450
FLG
FLG isoform 1.
   
 
 0.441
CDSN
Corneodesmosin; Important for the epidermal barrier integrity.
   
 
 0.410
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.