BECN2 protein (Pongo abelii) - STRING interaction network

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Score

BECN2

BECN2 isoform 1. (441 aa)

Predicted Functional Partners:

UVRAG

0.996

ATG14

0.996

PIK3C3

0.996

PIK3R4

0.996

ULK1

0.991

RB1CC1

0.990

AMBRA1

0.988

BCL2

0.988

ATG13

0.987

ULK2

0.982

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	ATG13	ENSPPYP00000003814	ENSPPYP00000003811	AMBRA1 isoform 3.	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	0.824
AMBRA1	ATG14	ENSPPYP00000003814	ENSPPYP00000006635	AMBRA1 isoform 3.	Autophagy related 14.	0.974
AMBRA1	BCL2	ENSPPYP00000003814	ENSPPYP00000010339	AMBRA1 isoform 3.	BCL2 isoform 1.	0.462
AMBRA1	BECN2	ENSPPYP00000003814	ENSPPYP00000000063	AMBRA1 isoform 3.	BECN2 isoform 1.	0.988
AMBRA1	PIK3C3	ENSPPYP00000003814	ENSPPYP00000010247	AMBRA1 isoform 3.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.977
AMBRA1	PIK3R4	ENSPPYP00000003814	ENSPPYP00000015770	AMBRA1 isoform 3.	Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).	0.975
AMBRA1	RB1CC1	ENSPPYP00000003814	ENSPPYP00000020840	AMBRA1 isoform 3.	RB1CC1 isoform 1.	0.781
AMBRA1	ULK1	ENSPPYP00000003814	ENSPPYP00000005848	AMBRA1 isoform 3.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.992
AMBRA1	ULK2	ENSPPYP00000003814	ENSPPYP00000009920	AMBRA1 isoform 3.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.979
AMBRA1	UVRAG	ENSPPYP00000003814	ENSPPYP00000004223	AMBRA1 isoform 3.	UV radiation resistance associated.	0.624
ATG13	AMBRA1	ENSPPYP00000003811	ENSPPYP00000003814	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	AMBRA1 isoform 3.	0.824
ATG13	ATG14	ENSPPYP00000003811	ENSPPYP00000006635	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	Autophagy related 14.	0.991
ATG13	BECN2	ENSPPYP00000003811	ENSPPYP00000000063	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	BECN2 isoform 1.	0.987
ATG13	PIK3C3	ENSPPYP00000003811	ENSPPYP00000010247	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.964
ATG13	PIK3R4	ENSPPYP00000003811	ENSPPYP00000015770	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).	0.985
ATG13	RB1CC1	ENSPPYP00000003811	ENSPPYP00000020840	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	RB1CC1 isoform 1.	0.999
ATG13	ULK1	ENSPPYP00000003811	ENSPPYP00000005848	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.999
ATG13	ULK2	ENSPPYP00000003811	ENSPPYP00000009920	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.998
ATG13	UVRAG	ENSPPYP00000003811	ENSPPYP00000004223	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	UV radiation resistance associated.	0.583
ATG14	AMBRA1	ENSPPYP00000006635	ENSPPYP00000003814	Autophagy related 14.	AMBRA1 isoform 3.	0.974