| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AK2 | AK8 | ENSPPYP00000001820 | ENSPPYP00000022108 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | AK8 isoform 2; Belongs to the adenylate kinase family. | 0.916 |
| AK2 | ENTPD1 | ENSPPYP00000001820 | ENSPPYP00000002915 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | ENTPD1 isoform 5; Belongs to the GDA1/CD39 NTPase family. | 0.671 |
| AK2 | ENTPD3 | ENSPPYP00000001820 | ENSPPYP00000015648 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | ENTPD3 isoform 1; Belongs to the GDA1/CD39 NTPase family. | 0.671 |
| AK2 | ENTPD8 | ENSPPYP00000001820 | ENSPPYP00000022232 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. | 0.682 |
| AK2 | NME2 | ENSPPYP00000001820 | ENSPPYP00000005726 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] | 0.783 |
| AK2 | NME3 | ENSPPYP00000001820 | ENSPPYP00000007881 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | Nucleoside diphosphate kinase. | 0.783 |
| AK2 | NME4 | ENSPPYP00000001820 | ENSPPYP00000007822 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | Nucleoside diphosphate kinase. | 0.838 |
| AK2 | NME6 | ENSPPYP00000001820 | ENSPPYP00000015557 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | Nucleoside diphosphate kinase. | 0.761 |
| AK2 | NTPCR | ENSPPYP00000001820 | ENSPPYP00000000108 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | Nucleoside-triphosphatase, cancer-related. | 0.964 |
| AK2 | RRM1 | ENSPPYP00000001820 | ENSPPYP00000004146 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.854 |
| AK8 | AK2 | ENSPPYP00000022108 | ENSPPYP00000001820 | AK8 isoform 2; Belongs to the adenylate kinase family. | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | 0.916 |
| AK8 | ENTPD1 | ENSPPYP00000022108 | ENSPPYP00000002915 | AK8 isoform 2; Belongs to the adenylate kinase family. | ENTPD1 isoform 5; Belongs to the GDA1/CD39 NTPase family. | 0.667 |
| AK8 | ENTPD3 | ENSPPYP00000022108 | ENSPPYP00000015648 | AK8 isoform 2; Belongs to the adenylate kinase family. | ENTPD3 isoform 1; Belongs to the GDA1/CD39 NTPase family. | 0.662 |
| AK8 | ENTPD8 | ENSPPYP00000022108 | ENSPPYP00000022232 | AK8 isoform 2; Belongs to the adenylate kinase family. | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. | 0.662 |
| AK8 | NME2 | ENSPPYP00000022108 | ENSPPYP00000005726 | AK8 isoform 2; Belongs to the adenylate kinase family. | Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] | 0.761 |
| AK8 | NME3 | ENSPPYP00000022108 | ENSPPYP00000007881 | AK8 isoform 2; Belongs to the adenylate kinase family. | Nucleoside diphosphate kinase. | 0.766 |
| AK8 | NME4 | ENSPPYP00000022108 | ENSPPYP00000007822 | AK8 isoform 2; Belongs to the adenylate kinase family. | Nucleoside diphosphate kinase. | 0.761 |
| AK8 | NME6 | ENSPPYP00000022108 | ENSPPYP00000015557 | AK8 isoform 2; Belongs to the adenylate kinase family. | Nucleoside diphosphate kinase. | 0.761 |
| AK8 | NTPCR | ENSPPYP00000022108 | ENSPPYP00000000108 | AK8 isoform 2; Belongs to the adenylate kinase family. | Nucleoside-triphosphatase, cancer-related. | 0.964 |
| AK8 | RRM1 | ENSPPYP00000022108 | ENSPPYP00000004146 | AK8 isoform 2; Belongs to the adenylate kinase family. | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.852 |
