| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NSFL1C | PLAA | ENSPPYP00000012121 | ENSPPYP00000021471 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | PLAA isoform 1. | 0.754 |
| NSFL1C | SPATA5 | ENSPPYP00000012121 | ENSPPYP00000016811 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | SPATA5 isoform 1. | 0.764 |
| NSFL1C | SPATA5L1 | ENSPPYP00000012121 | ENSPPYP00000007302 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | SPATA5L1 isoform 1. | 0.764 |
| NSFL1C | UBC | ENSPPYP00000012121 | ENSPPYP00000005811 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | UBC isoform 2. | 0.808 |
| NSFL1C | UBE4B | ENSPPYP00000012121 | ENSPPYP00000002206 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | UBE4B isoform 1. | 0.525 |
| NSFL1C | UBXN6 | ENSPPYP00000012121 | ENSPPYP00000010548 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | UBXN6 isoform 3. | 0.994 |
| NSFL1C | UFD1 | ENSPPYP00000012121 | ENSPPYP00000012917 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | Ubiquitin recognition factor in ER associated degradation 1. | 0.963 |
| NSFL1C | VCP | ENSPPYP00000012121 | ENSPPYP00000021408 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | Transitional endoplasmic reticulum ATPase isoform X1. | 0.999 |
| NSFL1C | YOD1 | ENSPPYP00000012121 | ENSPPYP00000000289 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | YOD1 deubiquitinase. | 0.754 |
| PLAA | NSFL1C | ENSPPYP00000021471 | ENSPPYP00000012121 | PLAA isoform 1. | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | 0.754 |
| PLAA | SPATA5 | ENSPPYP00000021471 | ENSPPYP00000016811 | PLAA isoform 1. | SPATA5 isoform 1. | 0.668 |
| PLAA | SPATA5L1 | ENSPPYP00000021471 | ENSPPYP00000007302 | PLAA isoform 1. | SPATA5L1 isoform 1. | 0.668 |
| PLAA | UBA52 | ENSPPYP00000021471 | ENSPPYP00000010917 | PLAA isoform 1. | UBA52 isoform 10. | 0.737 |
| PLAA | UBC | ENSPPYP00000021471 | ENSPPYP00000005811 | PLAA isoform 1. | UBC isoform 2. | 0.827 |
| PLAA | UBE4B | ENSPPYP00000021471 | ENSPPYP00000002206 | PLAA isoform 1. | UBE4B isoform 1. | 0.619 |
| PLAA | UBXN6 | ENSPPYP00000021471 | ENSPPYP00000010548 | PLAA isoform 1. | UBXN6 isoform 3. | 0.880 |
| PLAA | UFD1 | ENSPPYP00000021471 | ENSPPYP00000012917 | PLAA isoform 1. | Ubiquitin recognition factor in ER associated degradation 1. | 0.865 |
| PLAA | VCP | ENSPPYP00000021471 | ENSPPYP00000021408 | PLAA isoform 1. | Transitional endoplasmic reticulum ATPase isoform X1. | 0.966 |
| PLAA | YOD1 | ENSPPYP00000021471 | ENSPPYP00000000289 | PLAA isoform 1. | YOD1 deubiquitinase. | 0.858 |
| SPATA5 | NSFL1C | ENSPPYP00000016811 | ENSPPYP00000012121 | SPATA5 isoform 1. | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. | 0.764 |
