| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYLD | IKBKE | ENSPPYP00000008294 | ENSPPYP00000000308 | Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | 0.991 |
| CYLD | IKBKG | ENSPPYP00000008294 | ENSPPYP00000023381 | Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | 0.987 |
| CYLD | MAVS | ENSPPYP00000008294 | ENSPPYP00000012072 | Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] | MAVS isoform 2. | 0.613 |
| CYLD | TBK1 | ENSPPYP00000008294 | ENSPPYP00000005386 | Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] | TANK binding kinase 1. | 0.918 |
| CYLD | TRAF3 | ENSPPYP00000008294 | ENSPPYP00000007003 | Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.777 |
| IKBKE | CYLD | ENSPPYP00000000308 | ENSPPYP00000008294 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] | 0.991 |
| IKBKE | IKBKG | ENSPPYP00000000308 | ENSPPYP00000023381 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | 0.982 |
| IKBKE | IRF3 | ENSPPYP00000000308 | ENSPPYP00000011485 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | IRF3 isoform 6. | 0.999 |
| IKBKE | IRF7 | ENSPPYP00000000308 | ENSPPYP00000003337 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | IRF7 isoform 12. | 0.987 |
| IKBKE | MAVS | ENSPPYP00000000308 | ENSPPYP00000012072 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | MAVS isoform 2. | 0.973 |
| IKBKE | STAT1 | ENSPPYP00000000308 | ENSPPYP00000014555 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | Signal transducer and activator of transcription. | 0.986 |
| IKBKE | STING1 | ENSPPYP00000000308 | ENSPPYP00000017715 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | Transmembrane protein 173. | 0.995 |
| IKBKE | TANK | ENSPPYP00000000308 | ENSPPYP00000014373 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | TANK isoform 2. | 0.997 |
| IKBKE | TBK1 | ENSPPYP00000000308 | ENSPPYP00000005386 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | TANK binding kinase 1. | 0.999 |
| IKBKE | TRAF3 | ENSPPYP00000000308 | ENSPPYP00000007003 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.997 |
| IKBKG | CYLD | ENSPPYP00000023381 | ENSPPYP00000008294 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] | 0.987 |
| IKBKG | IKBKE | ENSPPYP00000023381 | ENSPPYP00000000308 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | 0.982 |
| IKBKG | IRF3 | ENSPPYP00000023381 | ENSPPYP00000011485 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | IRF3 isoform 6. | 0.942 |
| IKBKG | IRF7 | ENSPPYP00000023381 | ENSPPYP00000003337 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | IRF7 isoform 12. | 0.930 |
| IKBKG | MAVS | ENSPPYP00000023381 | ENSPPYP00000012072 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | MAVS isoform 2. | 0.988 |
