| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALDH18A1 | DHODH | ENSPPYP00000002911 | ENSPPYP00000008492 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | 0.512 |
| ALDH18A1 | DPYD | ENSPPYP00000002911 | ENSPPYP00000001308 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). | 0.680 |
| ALDH18A1 | ENSPPYP00000020084 | ENSPPYP00000002911 | ENSPPYP00000020084 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | annotation not available | 0.665 |
| ALDH18A1 | OAT | ENSPPYP00000002911 | ENSPPYP00000024470 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | OAT isoform 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.998 |
| ALDH18A1 | OTC | ENSPPYP00000002911 | ENSPPYP00000022656 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. | 0.624 |
| ALDH18A1 | PM20D1 | ENSPPYP00000002911 | ENSPPYP00000000316 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | PM20D1 isoform 2. | 0.562 |
| DHODH | ALDH18A1 | ENSPPYP00000008492 | ENSPPYP00000002911 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.512 |
| DHODH | PM20D1 | ENSPPYP00000008492 | ENSPPYP00000000316 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | PM20D1 isoform 2. | 0.582 |
| DPYD | ALDH18A1 | ENSPPYP00000001308 | ENSPPYP00000002911 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.680 |
| DPYD | PM20D1 | ENSPPYP00000001308 | ENSPPYP00000000316 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). | PM20D1 isoform 2. | 0.582 |
| ENSPPYP00000020084 | ALDH18A1 | ENSPPYP00000020084 | ENSPPYP00000002911 | annotation not available | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.665 |
| ENSPPYP00000020084 | OAT | ENSPPYP00000020084 | ENSPPYP00000024470 | annotation not available | OAT isoform 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.784 |
| ENSPPYP00000020084 | OTC | ENSPPYP00000020084 | ENSPPYP00000022656 | annotation not available | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. | 0.926 |
| ENSPPYP00000020084 | PM20D1 | ENSPPYP00000020084 | ENSPPYP00000000316 | annotation not available | PM20D1 isoform 2. | 0.558 |
| GK5 | PM20D1 | ENSPPYP00000015850 | ENSPPYP00000000316 | Glycerol kinase 5; Belongs to the FGGY kinase family. | PM20D1 isoform 2. | 0.637 |
| NUCKS1 | PM20D1 | ENSPPYP00000000319 | ENSPPYP00000000316 | NUCKS1 isoform 1. | PM20D1 isoform 2. | 0.690 |
| NUCKS1 | RAB29 | ENSPPYP00000000319 | ENSPPYP00000000318 | NUCKS1 isoform 1. | Ras-related protein Rab-7L1; The small GTPases Rab are key regulators in vesicle trafficking (By similarity). Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact cen [...] | 0.713 |
| NUCKS1 | SLC41A1 | ENSPPYP00000000319 | ENSPPYP00000000317 | NUCKS1 isoform 1. | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance; Belongs to the SLC41A transporter family. | 0.678 |
| OAT | ALDH18A1 | ENSPPYP00000024470 | ENSPPYP00000002911 | OAT isoform 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.998 |
| OAT | ENSPPYP00000020084 | ENSPPYP00000024470 | ENSPPYP00000020084 | OAT isoform 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | annotation not available | 0.784 |
