CFH protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3	CD46	ENSPPYP00000010608	ENSPPYP00000000275	C3 isoform 1.	Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).	0.963
C3	CFB	ENSPPYP00000010608	ENSPPYP00000018417	C3 isoform 1.	T0191046 isoform 1; Belongs to the peptidase S1 family.	0.987
C3	CFH	ENSPPYP00000010608	ENSPPYP00000000444	C3 isoform 1.	Complement factor H.	0.908
C3	CFHR2	ENSPPYP00000010608	ENSPPYP00000000442	C3 isoform 1.	Complement factor H related 2.	0.981
C3	CFHR4	ENSPPYP00000010608	ENSPPYP00000000443	C3 isoform 1.	CFHR3 isoform 1.	0.946
C3	CFI	ENSPPYP00000010608	ENSPPYP00000016746	C3 isoform 1.	Complement factor I heavy chain; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.	0.996
C3	CR201_G0022101	ENSPPYP00000010608	ENSPPYP00000000279	C3 isoform 1.	CR1 isoform 2.	0.959
CD46	C3	ENSPPYP00000000275	ENSPPYP00000010608	Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).	C3 isoform 1.	0.963
CD46	CFH	ENSPPYP00000000275	ENSPPYP00000000444	Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).	Complement factor H.	0.900
CD46	CFHR4	ENSPPYP00000000275	ENSPPYP00000000443	Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).	CFHR3 isoform 1.	0.478
CD46	CFI	ENSPPYP00000000275	ENSPPYP00000016746	Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).	Complement factor I heavy chain; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.	0.975
CD46	CR201_G0022101	ENSPPYP00000000275	ENSPPYP00000000279	Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).	CR1 isoform 2.	0.919
CD46	TNC	ENSPPYP00000000275	ENSPPYP00000021895	Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).	TNC isoform 1.	0.446
CD46	TNN	ENSPPYP00000000275	ENSPPYP00000000556	Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).	TNN isoform 1.	0.446
CD46	TNR	ENSPPYP00000000275	ENSPPYP00000000555	Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).	TNR isoform 1.	0.446
CFB	C3	ENSPPYP00000018417	ENSPPYP00000010608	T0191046 isoform 1; Belongs to the peptidase S1 family.	C3 isoform 1.	0.987
CFB	CFH	ENSPPYP00000018417	ENSPPYP00000000444	T0191046 isoform 1; Belongs to the peptidase S1 family.	Complement factor H.	0.903
CFB	CFHR2	ENSPPYP00000018417	ENSPPYP00000000442	T0191046 isoform 1; Belongs to the peptidase S1 family.	Complement factor H related 2.	0.722
CFB	CFHR4	ENSPPYP00000018417	ENSPPYP00000000443	T0191046 isoform 1; Belongs to the peptidase S1 family.	CFHR3 isoform 1.	0.569
CFB	CFI	ENSPPYP00000018417	ENSPPYP00000016746	T0191046 isoform 1; Belongs to the peptidase S1 family.	Complement factor I heavy chain; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.	0.704