| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CH25H | CR201_G0032337-2 | ENSPPYP00000002851 | ENSPPYP00000014972 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | CYP27A1 isoform 5. | 0.936 |
| CH25H | CYP46A1 | ENSPPYP00000002851 | ENSPPYP00000006975 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | CYP46A1 isoform 2; Belongs to the cytochrome P450 family. | 0.952 |
| CH25H | CYP7A1 | ENSPPYP00000002851 | ENSPPYP00000020869 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.968 |
| CH25H | DHCR24 | ENSPPYP00000002851 | ENSPPYP00000001525 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | DHCR24 isoform 1. | 0.912 |
| CH25H | DHCR7 | ENSPPYP00000002851 | ENSPPYP00000003422 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | DHCR7 isoform 1. | 0.946 |
| CH25H | SOAT1 | ENSPPYP00000002851 | ENSPPYP00000000531 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | O-acyltransferase. | 0.845 |
| CH25H | SOAT2 | ENSPPYP00000002851 | ENSPPYP00000005210 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | O-acyltransferase. | 0.845 |
| CR201_G0028793 | CYP46A1 | ENSPPYP00000007772 | ENSPPYP00000006975 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | CYP46A1 isoform 2; Belongs to the cytochrome P450 family. | 0.618 |
| CR201_G0028793 | CYP7A1 | ENSPPYP00000007772 | ENSPPYP00000020869 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.454 |
| CR201_G0028793 | DHCR24 | ENSPPYP00000007772 | ENSPPYP00000001525 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | DHCR24 isoform 1. | 0.826 |
| CR201_G0028793 | DHCR7 | ENSPPYP00000007772 | ENSPPYP00000003422 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | DHCR7 isoform 1. | 0.850 |
| CR201_G0028793 | SOAT1 | ENSPPYP00000007772 | ENSPPYP00000000531 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | O-acyltransferase. | 0.821 |
| CR201_G0028793 | SOAT2 | ENSPPYP00000007772 | ENSPPYP00000005210 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | O-acyltransferase. | 0.809 |
| CR201_G0028793 | STS | ENSPPYP00000007772 | ENSPPYP00000022489 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | STS isoform 1. | 0.910 |
| CR201_G0032337-2 | CH25H | ENSPPYP00000014972 | ENSPPYP00000002851 | CYP27A1 isoform 5. | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | 0.936 |
| CR201_G0032337-2 | CYP46A1 | ENSPPYP00000014972 | ENSPPYP00000006975 | CYP27A1 isoform 5. | CYP46A1 isoform 2; Belongs to the cytochrome P450 family. | 0.927 |
| CR201_G0032337-2 | CYP7A1 | ENSPPYP00000014972 | ENSPPYP00000020869 | CYP27A1 isoform 5. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.984 |
| CR201_G0032337-2 | DHCR24 | ENSPPYP00000014972 | ENSPPYP00000001525 | CYP27A1 isoform 5. | DHCR24 isoform 1. | 0.830 |
| CR201_G0032337-2 | DHCR7 | ENSPPYP00000014972 | ENSPPYP00000003422 | CYP27A1 isoform 5. | DHCR7 isoform 1. | 0.876 |
| CR201_G0032337-2 | SOAT1 | ENSPPYP00000014972 | ENSPPYP00000000531 | CYP27A1 isoform 5. | O-acyltransferase. | 0.834 |
