| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COP1 | CUL4A | ENSPPYP00000000553 | ENSPPYP00000006296 | COP1 E3 ubiquitin ligase. | CUL4A isoform 5; Belongs to the cullin family. | 0.956 |
| COP1 | CUL4B | ENSPPYP00000000553 | ENSPPYP00000023154 | COP1 E3 ubiquitin ligase. | CUL4B isoform 4; Belongs to the cullin family. | 0.926 |
| COP1 | DDB1 | ENSPPYP00000000553 | ENSPPYP00000003683 | COP1 E3 ubiquitin ligase. | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] | 0.979 |
| COP1 | DDB2 | ENSPPYP00000000553 | ENSPPYP00000003799 | COP1 E3 ubiquitin ligase. | Damage specific DNA binding protein 2. | 0.975 |
| COP1 | DET1 | ENSPPYP00000000553 | ENSPPYP00000007661 | COP1 E3 ubiquitin ligase. | DET1 isoform 5. | 0.986 |
| COP1 | ERCC8 | ENSPPYP00000000553 | ENSPPYP00000017309 | COP1 E3 ubiquitin ligase. | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. | 0.949 |
| COP1 | RBX1 | ENSPPYP00000000553 | ENSPPYP00000013235 | COP1 E3 ubiquitin ligase. | RBX1 isoform 1. | 0.939 |
| COP1 | TP53 | ENSPPYP00000000553 | ENSPPYP00000008923 | COP1 E3 ubiquitin ligase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.984 |
| COP1 | TRIB1 | ENSPPYP00000000553 | ENSPPYP00000021178 | COP1 E3 ubiquitin ligase. | Tribbles pseudokinase 1. | 0.933 |
| COP1 | TRIB3 | ENSPPYP00000000553 | ENSPPYP00000012140 | COP1 E3 ubiquitin ligase. | TRIB3 isoform 1. | 0.925 |
| CUL4A | COP1 | ENSPPYP00000006296 | ENSPPYP00000000553 | CUL4A isoform 5; Belongs to the cullin family. | COP1 E3 ubiquitin ligase. | 0.956 |
| CUL4A | CUL4B | ENSPPYP00000006296 | ENSPPYP00000023154 | CUL4A isoform 5; Belongs to the cullin family. | CUL4B isoform 4; Belongs to the cullin family. | 0.998 |
| CUL4A | DDB1 | ENSPPYP00000006296 | ENSPPYP00000003683 | CUL4A isoform 5; Belongs to the cullin family. | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] | 0.998 |
| CUL4A | DDB2 | ENSPPYP00000006296 | ENSPPYP00000003799 | CUL4A isoform 5; Belongs to the cullin family. | Damage specific DNA binding protein 2. | 0.988 |
| CUL4A | DET1 | ENSPPYP00000006296 | ENSPPYP00000007661 | CUL4A isoform 5; Belongs to the cullin family. | DET1 isoform 5. | 0.919 |
| CUL4A | ERCC8 | ENSPPYP00000006296 | ENSPPYP00000017309 | CUL4A isoform 5; Belongs to the cullin family. | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. | 0.967 |
| CUL4A | RBX1 | ENSPPYP00000006296 | ENSPPYP00000013235 | CUL4A isoform 5; Belongs to the cullin family. | RBX1 isoform 1. | 0.988 |
| CUL4A | TP53 | ENSPPYP00000006296 | ENSPPYP00000008923 | CUL4A isoform 5; Belongs to the cullin family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.669 |
| CUL4B | COP1 | ENSPPYP00000023154 | ENSPPYP00000000553 | CUL4B isoform 4; Belongs to the cullin family. | COP1 E3 ubiquitin ligase. | 0.926 |
| CUL4B | CUL4A | ENSPPYP00000023154 | ENSPPYP00000006296 | CUL4B isoform 4; Belongs to the cullin family. | CUL4A isoform 5; Belongs to the cullin family. | 0.998 |
