SERPINC1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOH	CR201_G0004084	ENSPPYP00000009611	ENSPPYP00000023892	APOH isoform 1.	LPA isoform 1.	0.781
APOH	F2	ENSPPYP00000009611	ENSPPYP00000003807	APOH isoform 1.	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	0.951
APOH	FGA	ENSPPYP00000009611	ENSPPYP00000016920	APOH isoform 1.	FGA isoform 1.	0.833
APOH	FGB	ENSPPYP00000009611	ENSPPYP00000016918	APOH isoform 1.	FGB isoform 1.	0.715
APOH	SERPINA3	ENSPPYP00000009611	ENSPPYP00000006946	APOH isoform 1.	Alpha-1-antichymotrypsin; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.	0.464
APOH	SERPINC1	ENSPPYP00000009611	ENSPPYP00000000566	APOH isoform 1.	Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).	0.929
CR201_G0004084	APOH	ENSPPYP00000023892	ENSPPYP00000009611	LPA isoform 1.	APOH isoform 1.	0.781
CR201_G0004084	F2	ENSPPYP00000023892	ENSPPYP00000003807	LPA isoform 1.	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	0.707
CR201_G0004084	FGA	ENSPPYP00000023892	ENSPPYP00000016920	LPA isoform 1.	FGA isoform 1.	0.929
CR201_G0004084	FGB	ENSPPYP00000023892	ENSPPYP00000016918	LPA isoform 1.	FGB isoform 1.	0.932
CR201_G0004084	SERPINC1	ENSPPYP00000023892	ENSPPYP00000000566	LPA isoform 1.	Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).	0.893
CR201_G0004084	SERPING1	ENSPPYP00000023892	ENSPPYP00000003756	LPA isoform 1.	SERPING1 isoform 3; Belongs to the serpin family.	0.464
F10	F2	ENSPPYP00000006293	ENSPPYP00000003807	Coagulation factor X.	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	0.979
F10	F9	ENSPPYP00000006293	ENSPPYP00000023262	Coagulation factor X.	F9 isoform 2.	0.809
F10	FGA	ENSPPYP00000006293	ENSPPYP00000016920	Coagulation factor X.	FGA isoform 1.	0.565
F10	FGB	ENSPPYP00000006293	ENSPPYP00000016918	Coagulation factor X.	FGB isoform 1.	0.470
F10	SERPINA3	ENSPPYP00000006293	ENSPPYP00000006946	Coagulation factor X.	Alpha-1-antichymotrypsin; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.	0.413
F10	SERPINA5	ENSPPYP00000006293	ENSPPYP00000006945	Coagulation factor X.	SERPINA5 isoform 1; Belongs to the serpin family.	0.444
F10	SERPINC1	ENSPPYP00000006293	ENSPPYP00000000566	Coagulation factor X.	Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).	0.933
F2	APOH	ENSPPYP00000003807	ENSPPYP00000009611	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	APOH isoform 1.	0.951