RGS4 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	GNAI3	ENSPPYP00000019671	ENSPPYP00000001241	Receptor protein-tyrosine kinase.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.545
EGFR	RGS4	ENSPPYP00000019671	ENSPPYP00000000674	Receptor protein-tyrosine kinase.	Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).	0.802
ENSPPYP00000002678	GNAI1	ENSPPYP00000002678	ENSPPYP00000020020	annotation not available	Guanine nucleotide-binding protein G(i) subunit alpha-1.	0.975
ENSPPYP00000002678	GNAI3	ENSPPYP00000002678	ENSPPYP00000001241	annotation not available	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.975
ENSPPYP00000002678	GNAO1	ENSPPYP00000002678	ENSPPYP00000008317	annotation not available	GNAO1 isoform 1.	0.666
ENSPPYP00000002678	GNAT3	ENSPPYP00000002678	ENSPPYP00000020019	annotation not available	GNAT3 isoform 1.	0.589
ENSPPYP00000002678	RGS4	ENSPPYP00000002678	ENSPPYP00000000674	annotation not available	Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).	0.682
GNA11	GNA14	ENSPPYP00000010507	ENSPPYP00000021632	GNA11 isoform 1.	G protein subunit alpha 14.	0.993
GNA11	GNAI3	ENSPPYP00000010507	ENSPPYP00000001241	GNA11 isoform 1.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.711
GNA11	GNAO1	ENSPPYP00000010507	ENSPPYP00000008317	GNA11 isoform 1.	GNAO1 isoform 1.	0.664
GNA11	GNAQ	ENSPPYP00000010507	ENSPPYP00000021633	GNA11 isoform 1.	G protein subunit alpha q.	0.997
GNA11	GNAT3	ENSPPYP00000010507	ENSPPYP00000020019	GNA11 isoform 1.	GNAT3 isoform 1.	0.630
GNA11	RGS4	ENSPPYP00000010507	ENSPPYP00000000674	GNA11 isoform 1.	Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).	0.706
GNA14	GNA11	ENSPPYP00000021632	ENSPPYP00000010507	G protein subunit alpha 14.	GNA11 isoform 1.	0.993
GNA14	GNAI3	ENSPPYP00000021632	ENSPPYP00000001241	G protein subunit alpha 14.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.695
GNA14	GNAO1	ENSPPYP00000021632	ENSPPYP00000008317	G protein subunit alpha 14.	GNAO1 isoform 1.	0.663
GNA14	GNAQ	ENSPPYP00000021632	ENSPPYP00000021633	G protein subunit alpha 14.	G protein subunit alpha q.	0.992
GNA14	GNAT3	ENSPPYP00000021632	ENSPPYP00000020019	G protein subunit alpha 14.	GNAT3 isoform 1.	0.629
GNA14	RGS4	ENSPPYP00000021632	ENSPPYP00000000674	G protein subunit alpha 14.	Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).	0.706
GNAI1	ENSPPYP00000002678	ENSPPYP00000020020	ENSPPYP00000002678	Guanine nucleotide-binding protein G(i) subunit alpha-1.	annotation not available	0.975