| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIM2 | CASP1 | ENSPPYP00000000773 | ENSPPYP00000004375 | Absent in melanoma 2. | CASP1 isoform 4; Belongs to the peptidase C14A family. | 0.993 |
| AIM2 | CASP5 | ENSPPYP00000000773 | ENSPPYP00000004374 | Absent in melanoma 2. | CASP5 isoform 2; Belongs to the peptidase C14A family. | 0.874 |
| AIM2 | CASP8 | ENSPPYP00000000773 | ENSPPYP00000014605 | Absent in melanoma 2. | CASP8 isoform 1; Belongs to the peptidase C14A family. | 0.934 |
| AIM2 | FADD | ENSPPYP00000000773 | ENSPPYP00000003427 | Absent in melanoma 2. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.916 |
| AIM2 | IFI16 | ENSPPYP00000000773 | ENSPPYP00000000774 | Absent in melanoma 2. | Gamma-interferon-inducible protein 16; Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA bi [...] | 0.928 |
| AIM2 | NLRP1 | ENSPPYP00000000773 | ENSPPYP00000008863 | Absent in melanoma 2. | NLR family pyrin domain containing 1. | 0.907 |
| AIM2 | PYCARD | ENSPPYP00000000773 | ENSPPYP00000008260 | Absent in melanoma 2. | PYD and CARD domain containing. | 0.998 |
| AIM2 | RIPK1 | ENSPPYP00000000773 | ENSPPYP00000018096 | Absent in melanoma 2. | Receptor interacting serine/threonine kinase 1. | 0.923 |
| AIM2 | RIPK3 | ENSPPYP00000000773 | ENSPPYP00000006485 | Absent in melanoma 2. | Receptor interacting serine/threonine kinase 3. | 0.924 |
| AIM2 | TP53BP1 | ENSPPYP00000000773 | ENSPPYP00000007267 | Absent in melanoma 2. | TP53BP1 isoform 3. | 0.924 |
| CASP1 | AIM2 | ENSPPYP00000004375 | ENSPPYP00000000773 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Absent in melanoma 2. | 0.993 |
| CASP1 | CASP5 | ENSPPYP00000004375 | ENSPPYP00000004374 | CASP1 isoform 4; Belongs to the peptidase C14A family. | CASP5 isoform 2; Belongs to the peptidase C14A family. | 0.774 |
| CASP1 | CASP8 | ENSPPYP00000004375 | ENSPPYP00000014605 | CASP1 isoform 4; Belongs to the peptidase C14A family. | CASP8 isoform 1; Belongs to the peptidase C14A family. | 0.971 |
| CASP1 | FADD | ENSPPYP00000004375 | ENSPPYP00000003427 | CASP1 isoform 4; Belongs to the peptidase C14A family. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.915 |
| CASP1 | IFI16 | ENSPPYP00000004375 | ENSPPYP00000000774 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Gamma-interferon-inducible protein 16; Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA bi [...] | 0.566 |
| CASP1 | NLRP1 | ENSPPYP00000004375 | ENSPPYP00000008863 | CASP1 isoform 4; Belongs to the peptidase C14A family. | NLR family pyrin domain containing 1. | 0.976 |
| CASP1 | PYCARD | ENSPPYP00000004375 | ENSPPYP00000008260 | CASP1 isoform 4; Belongs to the peptidase C14A family. | PYD and CARD domain containing. | 0.999 |
| CASP1 | RIPK1 | ENSPPYP00000004375 | ENSPPYP00000018096 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 1. | 0.902 |
| CASP1 | RIPK3 | ENSPPYP00000004375 | ENSPPYP00000006485 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 3. | 0.910 |
| CASP5 | AIM2 | ENSPPYP00000004374 | ENSPPYP00000000773 | CASP5 isoform 2; Belongs to the peptidase C14A family. | Absent in melanoma 2. | 0.874 |
