| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0006690 | SMG5 | ENSPPYP00000023142 | ENSPPYP00000000838 | UPF3B isoform 4. | SMG5 nonsense mediated mRNA decay factor. | 0.992 |
| CR201_G0006690 | SMG6 | ENSPPYP00000023142 | ENSPPYP00000008776 | UPF3B isoform 4. | Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). | 0.942 |
| CR201_G0006690 | SMG7 | ENSPPYP00000023142 | ENSPPYP00000000485 | UPF3B isoform 4. | SMG7 nonsense mediated mRNA decay factor. | 0.899 |
| CR201_G0006690 | SMG8 | ENSPPYP00000023142 | ENSPPYP00000009242 | UPF3B isoform 4. | Protein SMG8. | 0.447 |
| CR201_G0006690 | SMG9 | ENSPPYP00000023142 | ENSPPYP00000023744 | UPF3B isoform 4. | SMG9 nonsense mediated mRNA decay factor. | 0.485 |
| CR201_G0006690 | UPF1 | ENSPPYP00000023142 | ENSPPYP00000010923 | UPF3B isoform 4. | UPF1 isoform 2. | 0.994 |
| CR201_G0006690 | UPF2 | ENSPPYP00000023142 | ENSPPYP00000002423 | UPF3B isoform 4. | UPF2 isoform 1. | 0.993 |
| CR201_G0006690 | UPF3A | ENSPPYP00000023142 | ENSPPYP00000006310 | UPF3B isoform 4. | UPF3A regulator of nonsense mediated mRNA decay. | 0.916 |
| CR201_G0006690 | ZGRF1 | ENSPPYP00000023142 | ENSPPYP00000016762 | UPF3B isoform 4. | ZGRF1 isoform 9. | 0.823 |
| SMG5 | CR201_G0006690 | ENSPPYP00000000838 | ENSPPYP00000023142 | SMG5 nonsense mediated mRNA decay factor. | UPF3B isoform 4. | 0.992 |
| SMG5 | SMG6 | ENSPPYP00000000838 | ENSPPYP00000008776 | SMG5 nonsense mediated mRNA decay factor. | Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). | 0.988 |
| SMG5 | SMG7 | ENSPPYP00000000838 | ENSPPYP00000000485 | SMG5 nonsense mediated mRNA decay factor. | SMG7 nonsense mediated mRNA decay factor. | 0.989 |
| SMG5 | SMG8 | ENSPPYP00000000838 | ENSPPYP00000009242 | SMG5 nonsense mediated mRNA decay factor. | Protein SMG8. | 0.891 |
| SMG5 | SMG9 | ENSPPYP00000000838 | ENSPPYP00000023744 | SMG5 nonsense mediated mRNA decay factor. | SMG9 nonsense mediated mRNA decay factor. | 0.898 |
| SMG5 | TERT | ENSPPYP00000000838 | ENSPPYP00000017108 | SMG5 nonsense mediated mRNA decay factor. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.904 |
| SMG5 | UPF1 | ENSPPYP00000000838 | ENSPPYP00000010923 | SMG5 nonsense mediated mRNA decay factor. | UPF1 isoform 2. | 0.996 |
| SMG5 | UPF2 | ENSPPYP00000000838 | ENSPPYP00000002423 | SMG5 nonsense mediated mRNA decay factor. | UPF2 isoform 1. | 0.925 |
| SMG5 | UPF3A | ENSPPYP00000000838 | ENSPPYP00000006310 | SMG5 nonsense mediated mRNA decay factor. | UPF3A regulator of nonsense mediated mRNA decay. | 0.991 |
| SMG5 | ZGRF1 | ENSPPYP00000000838 | ENSPPYP00000016762 | SMG5 nonsense mediated mRNA decay factor. | ZGRF1 isoform 9. | 0.903 |
| SMG6 | CR201_G0006690 | ENSPPYP00000008776 | ENSPPYP00000023142 | Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). | UPF3B isoform 4. | 0.942 |
