| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGEF2 | CGN | ENSPPYP00000000851 | ENSPPYP00000001009 | Rho/Rac guanine nucleotide exchange factor 2. | CGN isoform 4. | 0.972 |
| ARHGEF2 | CGNL1 | ENSPPYP00000000851 | ENSPPYP00000007377 | Rho/Rac guanine nucleotide exchange factor 2. | CGNL1 isoform 2. | 0.922 |
| ARHGEF2 | CR201_G0028223 | ENSPPYP00000000851 | ENSPPYP00000002499 | Rho/Rac guanine nucleotide exchange factor 2. | YWHAZ isoform 22. | 0.802 |
| ARHGEF2 | ENSPPYP00000022918 | ENSPPYP00000000851 | ENSPPYP00000022918 | Rho/Rac guanine nucleotide exchange factor 2. | annotation not available | 0.802 |
| ARHGEF2 | PTK2 | ENSPPYP00000000851 | ENSPPYP00000021213 | Rho/Rac guanine nucleotide exchange factor 2. | PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.936 |
| ARHGEF2 | RHOA | ENSPPYP00000000851 | ENSPPYP00000015522 | Rho/Rac guanine nucleotide exchange factor 2. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.945 |
| ARHGEF2 | RHOC | ENSPPYP00000000851 | ENSPPYP00000001186 | Rho/Rac guanine nucleotide exchange factor 2. | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). | 0.884 |
| ARHGEF2 | RHOC-2 | ENSPPYP00000000851 | ENSPPYP00000011947 | Rho/Rac guanine nucleotide exchange factor 2. | RHOA isoform 3. | 0.793 |
| ARHGEF2 | RPP25L | ENSPPYP00000000851 | ENSPPYP00000022400 | Rho/Rac guanine nucleotide exchange factor 2. | RPP25L isoform 1. | 0.797 |
| ARHGEF2 | YWHAZ | ENSPPYP00000000851 | ENSPPYP00000021077 | Rho/Rac guanine nucleotide exchange factor 2. | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity); Belongs to the 14-3-3 family. | 0.802 |
| CGN | ARHGEF2 | ENSPPYP00000001009 | ENSPPYP00000000851 | CGN isoform 4. | Rho/Rac guanine nucleotide exchange factor 2. | 0.972 |
| CGN | RHOA | ENSPPYP00000001009 | ENSPPYP00000015522 | CGN isoform 4. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.696 |
| CGN | RHOC | ENSPPYP00000001009 | ENSPPYP00000001186 | CGN isoform 4. | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). | 0.631 |
| CGN | RHOC-2 | ENSPPYP00000001009 | ENSPPYP00000011947 | CGN isoform 4. | RHOA isoform 3. | 0.573 |
| CGNL1 | ARHGEF2 | ENSPPYP00000007377 | ENSPPYP00000000851 | CGNL1 isoform 2. | Rho/Rac guanine nucleotide exchange factor 2. | 0.922 |
| CR201_G0028223 | ARHGEF2 | ENSPPYP00000002499 | ENSPPYP00000000851 | YWHAZ isoform 22. | Rho/Rac guanine nucleotide exchange factor 2. | 0.802 |
| ENSPPYP00000022918 | ARHGEF2 | ENSPPYP00000022918 | ENSPPYP00000000851 | annotation not available | Rho/Rac guanine nucleotide exchange factor 2. | 0.802 |
| PTK2 | ARHGEF2 | ENSPPYP00000021213 | ENSPPYP00000000851 | PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family. | Rho/Rac guanine nucleotide exchange factor 2. | 0.936 |
| PTK2 | RHOA | ENSPPYP00000021213 | ENSPPYP00000015522 | PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.687 |
| PTK2 | RHOC | ENSPPYP00000021213 | ENSPPYP00000001186 | PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family. | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). | 0.571 |
